| Dextromethorphan-induced delirium and possible methadone interaction. | |
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MedLine Citation:
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PMID: 16089243 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Dextromethorphan is a commonly used antitussive agent that can be purchased over the counter. It is metabolized primarily by the cytochrome P450 (CYP) 2D6 isozyme. Methadone has been found to inhibit CYP2D6, indicating a potential for interaction with dextromethorphan. CASE SUMMARY: An 83-year-old woman was evaluated for delirium, hypersomnia, confusion, lethargy, impaired concentration, and poor food intake. Symptoms resolved soon after discontinuing dextromethorphan. DISCUSSION: Vulnerability to delirium was potentially caused by coadministration of methadone, which can inhibit the CYP2D6 isozyme. CONCLUSION: Evaluation of delirium should include close investigation of the patient's medications for potential interactions with dextromethorphan. |
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Authors:
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Francis E Lotrich; Jules Rosen; Bruce G Pollock |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American journal of geriatric pharmacotherapy Volume: 3 ISSN: 1543-5946 ISO Abbreviation: Am J Geriatr Pharmacother Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-08-10 Completed Date: 2005-08-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101190325 Medline TA: Am J Geriatr Pharmacother Country: United States |
Other Details:
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Languages: eng Pagination: 17-20 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA. lotrichfe@upmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Analgesics, Opioid / adverse effects*, therapeutic use Antitussive Agents / adverse effects*, therapeutic use Cough / complications, drug therapy Delirium / chemically induced*, psychology Depressive Disorder / complications, drug therapy Dextromethorphan / adverse effects*, therapeutic use Drug Interactions Female Humans Methadone / adverse effects*, therapeutic use Pain / drug therapy, psychology Serotonin Uptake Inhibitors / therapeutic use Sertraline / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Antitussive Agents; 0/Serotonin Uptake Inhibitors; 125-71-3/Dextromethorphan; 76-99-3/Methadone; 79617-96-2/Sertraline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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