Document Detail

Dextromethorphan alters the reinforcing effect of cocaine in the rat.
MedLine Citation:
PMID:  9500126     Owner:  NLM     Status:  MEDLINE    
Dextromethorphan (DM) at supra-antitussive doses produces psychotomimetic effects in humans. In order to achieve a better understanding of the pharmacological mechanisms responsible for the behaviors induced by DM, we examined the effects of DM on the intravenous self-administration of cocaine in the rat. The effects of DM (40 mg/kg, p.o.) on responding for 0.5, 0.25, 0.125, 0.06 and 0.03 mg/kg/infusion of cocaine was assessed. DM decreased the rate of responding for higher doses of cocaine (0.5, 0.25 and 0.125 mg/kg/infusion), and increased the rate of responding for lower doses of cocaine (0.06 and 0.03 mg/kg/infusion), suggesting that DM shifted the dose-response curve for cocaine self-administration to the left. Therefore, our results indicate that the sensitivity to cocaine's behavioral effects appears to be enhanced by DM.
H C Kim; B K Park; S Y Hong; W K Jhoo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Methods and findings in experimental and clinical pharmacology     Volume:  19     ISSN:  0379-0355     ISO Abbreviation:  Methods Find Exp Clin Pharmacol     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-04-27     Completed Date:  1998-04-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909595     Medline TA:  Methods Find Exp Clin Pharmacol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  627-31     Citation Subset:  IM    
Department of Pharmacy, College of Pharmacy, Kangwon National University, Chunchon, Korea.
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MeSH Terms
Antitussive Agents / administration & dosage,  pharmacology*
Behavior, Animal / drug effects*
Cocaine / administration & dosage,  pharmacology*
Dextromethorphan / administration & dosage,  pharmacology*
Dopamine Uptake Inhibitors / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Drug Interactions
Infusions, Intravenous
Rats, Sprague-Dawley
Self Administration
Reg. No./Substance:
0/Antitussive Agents; 0/Dopamine Uptake Inhibitors; 125-71-3/Dextromethorphan; 50-36-2/Cocaine

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