Document Detail

Dextrans and the formation of pulmonary metastases after intravenous tumour cell injection in rats non-sensitive to dextran.
MedLine Citation:
PMID:  1183458     Owner:  NLM     Status:  MEDLINE    
This study showed, that in a syngeneic tumour-host system in rats non-sensitive to dextran, dextran 40 and dextran 100 did not stimulate metastasis formation after intravenous tumour cell injection, neither when given as intravenous pretreatment nor when given in the tumour cell suspension. Dextran 1000 stimulated the formation of metastases in both these situations. Disturbed microcirculation, intravascular coagulation and effects upon the tumour cell membrane appear to be the main resons, why dextran 1000 stimulated metastasis formation under the experimental conditions used.
L Ivarsson; C M Rudenstam
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes     Volume:  7     ISSN:  0014-312X     ISO Abbreviation:  Eur Surg Res     Publication Date:  1975  
Date Detail:
Created Date:  1976-01-23     Completed Date:  1976-01-23     Revised Date:  2006-11-30    
Medline Journal Info:
Nlm Unique ID:  0174752     Medline TA:  Eur Surg Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  326-40     Citation Subset:  IM    
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MeSH Terms
Cell Transformation, Neoplastic / drug effects*
Dextrans / administration & dosage,  pharmacology*
Lung Neoplasms*
Neoplasm Metastasis*
Neoplasm Transplantation
Rats, Inbred Strains
Sarcoma, Experimental*
Stimulation, Chemical
Transplantation, Isogeneic
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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