| Dextran gadolinium complexes as contrast agents for magnetic resonance imaging to sentinel lymph nodes. | |
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MedLine Citation:
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PMID: 20559699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The aim was to investigate three dextran gadolinium complexes Dextran-DTPA-Gd as the potential MRI contrast agents in lymphatic system. METHODS: Three dextran gadolinium complexes Dextran-DTPA-Gd containing differing amounts of Gd-DTPA were synthesized by the incorporation of Gd-DTPA to the hydroxyl groups of dextran. These dextran ligands and gadolinium complexes were characterized, and their properties in vitro and in vivo were also evaluated. RESULTS: Dextran-DTPA-Gd demonstrated obviously higher relaxation effectiveness than that of Gd-DTPA. The result of in vitro cytotoxicity assay showed that these macromolecular ligands and their corresponding gadolinium complexes had low cytotoxicity to HeLa cells. Dextran-DTPA-Gd greatly enhanced the contrast of MR images of normal politeal lymph nodes and reactive hyperplasia of politeal lymph nodes in rabbits and provided prolonged duration in lymphatic system with lower injection doses than that of Gd-DTPA. However, Dextran-DTPA-Gd displayed low signal enhancements in MR images of politeal lymph nodes with VX2 carcinoma in rabbits during the detection time. CONCLUSIONS: These dextran gadolinium complexes Dextran-DTPA-Gd can be taken up selectively by lymphatic system and showed the potential as MRI contrast agents in lymphatic system. |
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Authors:
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Guo-Ping Yan; Wei Xu; Lian Yang; Liang Li; Fan Liu; Qing-Zhong Guo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-18 |
Journal Detail:
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Title: Pharmaceutical research Volume: 27 ISSN: 1573-904X ISO Abbreviation: Pharm. Res. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-05 Completed Date: 2010-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8406521 Medline TA: Pharm Res Country: United States |
Other Details:
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Languages: eng Pagination: 1884-92 Citation Subset: IM |
Affiliation:
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School of Material Science and Engineering, Wuhan Institute of Technology, Wuhan 430074, China. guopyan2006@163.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Survival / drug effects Contrast Media / chemistry*, diagnostic use, pharmacokinetics, pharmacology Dextrans / chemistry*, diagnostic use, pharmacokinetics, pharmacology Gadolinium DTPA / chemistry*, diagnostic use, pharmacokinetics, pharmacology Hela Cells Humans Lymph Nodes / metabolism, pathology* Magnetic Resonance Imaging* Neoplasms, Experimental / pathology Particle Size Rabbits |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/dextran-(gadolinium-DTPA)15; 80529-93-7/Gadolinium DTPA; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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