Document Detail


Dexmedetomidine versus midazolam in outpatient third molar surgery.
MedLine Citation:
PMID:  16916668     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The aim of this study was to compare the use of dexmedetomidine with the use of midazolam during intravenous conscious sedation in third molar surgery. PATIENTS AND METHODS: Twenty healthy patients with symmetrically impacted mandibular third molars were included in this double-blind, crossover, randomized study. Either dexmedetomidine (group D) (4 microg.kg(-1).h(-1)) or midazolam (group M) (0.4 mg.kg(-1).h(-1)) was administered intravenously for 15 minutes before the first operation. At the second operation, the other agent was applied. Cardiorespiratory data were collected. The intraoperative sedation level, patient cooperation, and postoperative performance were scored and any pain reaction during the local anesthetic injection was recorded. Visual analog scales were additionally used for the subjective assessment of pain and patient satisfaction. Amnesia was evaluated by the patients' ability to recall the objects shown during the operations and the local anesthetic injection. Patients' preferences were recorded during the interview at the end of the second operations. RESULTS: The mean heart rate and blood pressure measurements were significantly lower in group D. There was no significant difference in the respiratory findings. A significantly higher number of patients showed pain reactions in group M. Sedation level, postoperative performance, and VAS pain scores were not statistically significant, whereas the differences in cooperation score and VAS for patient satisfaction were significant. Adequate amnesia was obtained in group M, however, no amnesia was demonstrated in group D. Sixty-five percent of the patients indicated a preference for dexmedetomidine sedation. CONCLUSION: Dexmedetomidine may be a remarkable alternative to midazolam for intravenous sedation because it seems to be a reliable and safe method, with additional analgesic effect providing a satisfactory sedation level without any serious side effects during impacted third molar surgery.
Authors:
Yakup Ustün; Murat Gündüz; Ozgür Erdoğan; M Emre Benlidayi
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons     Volume:  64     ISSN:  0278-2391     ISO Abbreviation:  J. Oral Maxillofac. Surg.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-18     Completed Date:  2006-09-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8206428     Medline TA:  J Oral Maxillofac Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1353-8     Citation Subset:  AIM; D; IM    
Affiliation:
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cukurova University, Adana, Turkey. yustun@cu.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Ambulatory Care*
Anesthetics, Intravenous / administration & dosage
Blood Pressure / drug effects
Conscious Sedation
Cooperative Behavior
Cross-Over Studies
Dexmedetomidine / administration & dosage*
Double-Blind Method
Heart Rate / drug effects
Humans
Hypnotics and Sedatives / administration & dosage*
Injections, Intravenous / adverse effects
Memory / drug effects
Midazolam / administration & dosage*
Molar, Third / surgery*
Pain Measurement
Patient Satisfaction
Prospective Studies
Respiration / drug effects
Tooth Extraction*
Tooth, Impacted / surgery*
Chemical
Reg. No./Substance:
0/Anesthetics, Intravenous; 0/Hypnotics and Sedatives; 113775-47-6/Dexmedetomidine; 59467-70-8/Midazolam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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