| Dexmedetomidine versus midazolam in outpatient third molar surgery. | |
| | |
MedLine Citation:
|
PMID: 16916668 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: The aim of this study was to compare the use of dexmedetomidine with the use of midazolam during intravenous conscious sedation in third molar surgery. PATIENTS AND METHODS: Twenty healthy patients with symmetrically impacted mandibular third molars were included in this double-blind, crossover, randomized study. Either dexmedetomidine (group D) (4 microg.kg(-1).h(-1)) or midazolam (group M) (0.4 mg.kg(-1).h(-1)) was administered intravenously for 15 minutes before the first operation. At the second operation, the other agent was applied. Cardiorespiratory data were collected. The intraoperative sedation level, patient cooperation, and postoperative performance were scored and any pain reaction during the local anesthetic injection was recorded. Visual analog scales were additionally used for the subjective assessment of pain and patient satisfaction. Amnesia was evaluated by the patients' ability to recall the objects shown during the operations and the local anesthetic injection. Patients' preferences were recorded during the interview at the end of the second operations. RESULTS: The mean heart rate and blood pressure measurements were significantly lower in group D. There was no significant difference in the respiratory findings. A significantly higher number of patients showed pain reactions in group M. Sedation level, postoperative performance, and VAS pain scores were not statistically significant, whereas the differences in cooperation score and VAS for patient satisfaction were significant. Adequate amnesia was obtained in group M, however, no amnesia was demonstrated in group D. Sixty-five percent of the patients indicated a preference for dexmedetomidine sedation. CONCLUSION: Dexmedetomidine may be a remarkable alternative to midazolam for intravenous sedation because it seems to be a reliable and safe method, with additional analgesic effect providing a satisfactory sedation level without any serious side effects during impacted third molar surgery. |
| | |
Authors:
|
Yakup Ustün; Murat Gündüz; Ozgür Erdoğan; M Emre Benlidayi |
Related Documents
:
|
17697218 - A study of airway management using the proseal lma laryngeal mask airway compared with ... 20636988 - Outcome from status epilepticus after portosystemic shunt attenuation in 3 dogs treated... 15681938 - Impact of anesthesia management characteristics on severe morbidity and mortality. 20736428 - Oral contrast for abdominal computed tomography in children: the effects on gastric flu... 1635108 - The clinical significance of myocardial contusion. 9052468 - Transurethral vaporization of the prostate: a promising new technique. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons Volume: 64 ISSN: 0278-2391 ISO Abbreviation: J. Oral Maxillofac. Surg. Publication Date: 2006 Sep |
Date Detail:
|
Created Date: 2006-08-18 Completed Date: 2006-09-28 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8206428 Medline TA: J Oral Maxillofac Surg Country: United States |
Other Details:
|
Languages: eng Pagination: 1353-8 Citation Subset: AIM; D; IM |
Affiliation:
|
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cukurova University, Adana, Turkey. yustun@cu.edu.tr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Ambulatory Care* Anesthetics, Intravenous / administration & dosage Blood Pressure / drug effects Conscious Sedation Cooperative Behavior Cross-Over Studies Dexmedetomidine / administration & dosage* Double-Blind Method Heart Rate / drug effects Humans Hypnotics and Sedatives / administration & dosage* Injections, Intravenous / adverse effects Memory / drug effects Midazolam / administration & dosage* Molar, Third / surgery* Pain Measurement Patient Satisfaction Prospective Studies Respiration / drug effects Tooth Extraction* Tooth, Impacted / surgery* |
| Chemical | |
Reg. No./Substance:
|
0/Anesthetics, Intravenous; 0/Hypnotics and Sedatives; 113775-47-6/Dexmedetomidine; 59467-70-8/Midazolam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relative frequency of central odontogenic tumors: a study of 1,088 cases from Northern California an...
Next Document: Smoking may affect the alveolar process dimensions and radiographic bone density in maxillary extrac...