| Dexmedetomidine for the treatment of paroxysmal autonomic instability with dystonia. | |
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MedLine Citation:
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PMID: 17603760 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: A 38-year-old man with severe head trauma complicated by paroxysmal severe intracranial pressure elevation associated with tachypnea, tachycardia, diaphoresis, and extensor posturing was diagnosed as suffering from paroxysmal autonomic instability with dystonia (PAID). These events were unresponsive to standard medical therapy, which included morphine, fentanyl, labetalol, lorazepam, metoprolol, and clonidine. METHODS: A trial treatment with dexmedetomidine, a central acting alpha2-agonist, to control symptoms of PAID was initiated 12 days after injury. PAID-related events subsided during the 72-h infusion protocol of 0.2-0.7 mcg/kg/h. No further events were noted after termination of the 72-h infusion. CONCLUSIONS: Dexmedetomidine may be a novel pharmacologic agent to aid in abrogating PAID. |
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Authors:
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Richard P Goddeau; Scott B Silverman; John R Sims |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Neurocritical care Volume: 7 ISSN: 1541-6933 ISO Abbreviation: Neurocrit Care Publication Date: 2007 |
Date Detail:
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Created Date: 2007-11-16 Completed Date: 2008-03-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101156086 Medline TA: Neurocrit Care Country: United States |
Other Details:
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Languages: eng Pagination: 217-20 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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therapeutic use* Adult Autonomic Nervous System Diseases / drug therapy*, etiology Brain Injuries / complications*, drug therapy Dexmedetomidine / therapeutic use* Dystonia / drug therapy*, etiology Humans Male |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 113775-47-6/Dexmedetomidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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