| Dexmedetomidine sedation for carotid endarterectomy. | |
| | |
MedLine Citation:
|
PMID: 19697824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: General anaesthesia and deep sedation during endarterectomy exclude direct contact with the patient, required for safe performance of the surgery. The aim of the study was to assess sedation with dexmedetomidine and its cardiovascular effects. METHODS: Sixty-four adult patients, scheduled on internal carotid artery surgery under infiltration analgesia, were randomly divided to receive dexmedetomidine in the loading dose of 1 microg kg(-1) over 10 min, followed by 0.2 microg kg(-1) h(-1) continuous infusion (group D) or placebo (group P).The BIS score, heart rate (HR) and mean arterial pressure (MAP) were noted. RESULTS: In the group D, during carotid artery clamping (CAC) mean BIS scores were lower, compared to the baseline and to the values recorded in the group P. The BIS scores in the group P did not differ from baseline. In the group D, we did not observe cardiovascular reactions that could be attributed to CAC; in the group P, MAP and HR increased during CAC, and returned to normal 10 min after clamp release. Significant decrease of HR was observed after 12 min of dexmedetomidine infusion, at 10 and 15 min after CAC in group D. Urapidil and fentanyl were administered more often in the placebo group. CONCLUSIONS: The 0.2 microg kg(-1) h(-1) dexmedetomidine infusion, administered during carotid endarterectomy, secured cardiovascular stability and reduced the need for additional analgesia. |
| | |
Authors:
|
Magdalena Sidorowicz; Radosław Owczuk; Barbara Kwiecińska; Magdalena A Wujtewicz; Jacek Wojciechowski; Maria Wujtewicz |
Related Documents
:
|
9870284 - Office-based surgery and anesthesia: where are we now? 17321264 - A pilot study to assess the safety and efficacy of carbon dioxide insufflation during c... 7943694 - A comparison of the effect on gastric emptying of either enflurane or propofol given du... 20820154 - Patient safety in anesthesia. 14763704 - Increased mortality after fracture of the surgical neck of the humerus: a case-control ... 8729884 - Evaluation of the use of cefuroxime and cefuroxime axetil in an intravenous-oral stepdo... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Anestezjologia intensywna terapia Volume: 41 ISSN: 0209-1712 ISO Abbreviation: Anestezjol Intens Ter Publication Date: 2009 Apr-Jun |
Date Detail:
|
Created Date: 2009-08-24 Completed Date: 2009-09-22 Revised Date: 2012-10-05 |
Medline Journal Info:
|
Nlm Unique ID: 9424972 Medline TA: Anestezjol Intens Ter Country: Poland |
Other Details:
|
Languages: eng Pagination: 78-83 Citation Subset: IM |
Affiliation:
|
Department of Anaesthesiology and Intensive Therapy, Medical University of Gdańsk. sidor@amg.gda.pl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adjuvants, Anesthesia
/
administration & dosage Aged Anesthetics, Intravenous Dexmedetomidine / administration & dosage* Endarterectomy, Carotid / methods* Ephedrine / administration & dosage Female Fentanyl / administration & dosage Hemodynamics / drug effects* Humans Hypnotics and Sedatives / administration & dosage* Infusions, Intravenous Male Meperidine / administration & dosage Piperazines / administration & dosage Premedication* |
| Chemical | |
Reg. No./Substance:
|
0/Adjuvants, Anesthesia; 0/Anesthetics, Intravenous; 0/Hypnotics and Sedatives; 0/Piperazines; 113775-47-6/Dexmedetomidine; 299-42-3/Ephedrine; 34661-75-1/urapidil; 437-38-7/Fentanyl; 57-42-1/Meperidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: [Classic laryngeal mask airway vs COBRA-PLA device for airway maintenance during minor urological pr...
Next Document: [Patient-controlled continuous epidural analgesia vs intravenous remifentanil infusion for labour an...