Document Detail

Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery.
MedLine Citation:
PMID:  19567759     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Delirium is a neurobehavioral syndrome caused by the transient disruption of normal neuronal activity secondary to systemic disturbances. OBJECTIVE: The authors investigated the effects of postoperative sedation on the development of delirium in patients undergoing cardiac-valve procedures. METHODS: Patients underwent elective cardiac surgery with a standardized intraoperative anesthesia protocol, followed by random assignment to one of three postoperative sedation protocols: dexmedetomidine, propofol, or midazolam. RESULTS: The incidence of delirium for patients receiving dexmedetomidine was 3%, for those receiving propofol was 50%, and for patients receiving midazolam, 50%. Patients who developed postoperative delirium experienced significantly longer intensive-care stays and longer total hospitalization. CONCLUSION: The findings of this open-label, randomized clinical investigation suggest that postoperative sedation with dexmedetomidine was associated with significantly lower rates of postoperative delirium and lower care costs.
José R Maldonado; Ashley Wysong; Pieter J A van der Starre; Thaddeus Block; Craig Miller; Bruce A Reitz
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Psychosomatics     Volume:  50     ISSN:  1545-7206     ISO Abbreviation:  Psychosomatics     Publication Date:    2009 May-Jun
Date Detail:
Created Date:  2009-07-01     Completed Date:  2009-10-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376506     Medline TA:  Psychosomatics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  206-17     Citation Subset:  IM    
Dept. of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd., Suite 2317, Stanford, CA 94305-5546, USA.
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MeSH Terms
Cardiopulmonary Bypass*
Delirium / chemically induced,  diagnosis,  drug therapy*
Dexmedetomidine / adverse effects,  therapeutic use*
Dose-Response Relationship, Drug
Drug Administration Schedule
Follow-Up Studies
Heart Valve Diseases / surgery*
Heart Valve Prosthesis Implantation
Hypnotics and Sedatives / adverse effects,  therapeutic use*
Intensive Care Units
Midazolam / adverse effects,  therapeutic use
Middle Aged
Neuropsychological Tests
Postoperative Complications / diagnosis,  drug therapy*
Propofol / adverse effects,  therapeutic use
Reg. No./Substance:
0/Hypnotics and Sedatives; 113775-47-6/Dexmedetomidine; 2078-54-8/Propofol; 59467-70-8/Midazolam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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