| Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery. | |
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MedLine Citation:
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PMID: 19567759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Delirium is a neurobehavioral syndrome caused by the transient disruption of normal neuronal activity secondary to systemic disturbances. OBJECTIVE: The authors investigated the effects of postoperative sedation on the development of delirium in patients undergoing cardiac-valve procedures. METHODS: Patients underwent elective cardiac surgery with a standardized intraoperative anesthesia protocol, followed by random assignment to one of three postoperative sedation protocols: dexmedetomidine, propofol, or midazolam. RESULTS: The incidence of delirium for patients receiving dexmedetomidine was 3%, for those receiving propofol was 50%, and for patients receiving midazolam, 50%. Patients who developed postoperative delirium experienced significantly longer intensive-care stays and longer total hospitalization. CONCLUSION: The findings of this open-label, randomized clinical investigation suggest that postoperative sedation with dexmedetomidine was associated with significantly lower rates of postoperative delirium and lower care costs. |
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Authors:
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José R Maldonado; Ashley Wysong; Pieter J A van der Starre; Thaddeus Block; Craig Miller; Bruce A Reitz |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Psychosomatics Volume: 50 ISSN: 1545-7206 ISO Abbreviation: Psychosomatics Publication Date: 2009 May-Jun |
Date Detail:
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Created Date: 2009-07-01 Completed Date: 2009-10-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376506 Medline TA: Psychosomatics Country: United States |
Other Details:
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Languages: eng Pagination: 206-17 Citation Subset: IM |
Affiliation:
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Dept. of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd., Suite 2317, Stanford, CA 94305-5546, USA. jrm@stanford.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiopulmonary Bypass* Delirium / chemically induced, diagnosis, drug therapy* Dexmedetomidine / adverse effects, therapeutic use* Dose-Response Relationship, Drug Drug Administration Schedule Female Follow-Up Studies Heart Valve Diseases / surgery* Heart Valve Prosthesis Implantation Humans Hypnotics and Sedatives / adverse effects, therapeutic use* Intensive Care Units Male Midazolam / adverse effects, therapeutic use Middle Aged Neuropsychological Tests Postoperative Complications / diagnosis, drug therapy* Propofol / adverse effects, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Hypnotics and Sedatives; 113775-47-6/Dexmedetomidine; 2078-54-8/Propofol; 59467-70-8/Midazolam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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