Document Detail


Dexmedetomidine: a novel sedative-analgesic agent.
MedLine Citation:
PMID:  16369581     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Since the first report of clonidine, an alpha2-adrenoceptor agonist, the indications for this class of drugs have continued to expand. In December 1999, dexmedetomidine was approved as the most recent agent in this group and was introduced into clinical practice as a short-term sedative (<24 hours). Alpha2-adrenoceptor agonists have several beneficial actions during the perioperative period. They decrease sympathetic tone, with attenuation of the neuroendocrine and hemodynamic responses to anesthesia and surgery; reduce anesthetic and opioid requirements; and cause sedation and analgesia. They allow psychomotoric function to be preserved while letting the patient rest comfortably. With this combination of effects, alpha2-adrenoceptor agonists may offer benefits in the prophylaxis and adjuvant treatment of perioperative myocardial ischemia. Furthermore, their role in pain management and regional anesthesia is expanding. Side effects consist of mild to moderate cardiovascular depression, with slight decreases in blood pressure and heart rate. The development of new, more selective alpha2-adrenoceptor agonists with improved side effect profiles may provide a new concept for the administration of perioperative anesthesia and analgesia. This review aims to give background information to improve understanding of the properties and applications of the novel alpha2-adrenoceptor agonist, dexmedetomidine.
Authors:
R Gertler; H C Brown; D H Mitchell; E N Silvius
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings (Baylor University. Medical Center)     Volume:  14     ISSN:  0899-8280     ISO Abbreviation:  Proc (Bayl Univ Med Cent)     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2005-12-21     Completed Date:  2006-01-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9302033     Medline TA:  Proc (Bayl Univ Med Cent)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13-21     Citation Subset:  -    
Affiliation:
Department of Anesthesiology and Pain Management, Baylor University Medical Center, Dallas, Texas 75246, USA. Ralph_Gertler10@excite.com
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