Document Detail


Dexmedetomidine modulates cardiovascular responses to stimulation of central nervous system pressor sites.
MedLine Citation:
PMID:  10072017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
IMPLICATIONS: A new potential anesthetic adjunct, dexmedetomidine, does not attenuate brain-mediated increases in blood pressure, but the combination of dexmedetomidine and the anesthetic halothane acts to modulate central cardiovascular responses.
Authors:
N E Farber; E Samso; M Staunton; D Schwabe; W T Schmeling
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  88     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-03-25     Completed Date:  1999-03-25     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  617-24     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesiology, The Medical College of Wisconsin, Milwaukee 53226, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / pharmacology*
Anesthetics, Inhalation / pharmacology
Animals
Blood Pressure / drug effects,  physiology
Cardiovascular System / innervation*
Cats
Central Nervous System / drug effects*,  physiology
Drug Interactions
Electric Stimulation
Halothane / pharmacology
Heart Rate / drug effects,  physiology
Imidazoles / pharmacology*
Medetomidine
Pressoreceptors / drug effects*,  physiology
Receptors, Adrenergic, alpha-2 / physiology
Grant Support
ID/Acronym/Agency:
R01 GM 56398-01/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Anesthetics, Inhalation; 0/Imidazoles; 0/Receptors, Adrenergic, alpha-2; 151-67-7/Halothane; 86347-14-0/Medetomidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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