Document Detail

Dexmedetomidine-induced pulmonary alterations in sheep.
MedLine Citation:
PMID:  17224166     Owner:  NLM     Status:  MEDLINE    
Alpha(2) agonist-induced pulmonary oedema in sheep might be related to alterations in pulmonary haemodynamics and/or activation of inflammatory processes. In seven sevoflurane-anaesthetized sheep pulmonary haemodynamics, arterial oxygen tensions, nitric oxide and prostaglandin E(2) concentrations were determined before and after intravenous dexmedetomidine (2microg kg(-1)). In a second trial, lung tissue was sampled for histopathology and quantitative real-time PCR for IL-1beta and iNOS mRNA in a control sheep and 2, 10 and 30min after dexmedetomidine. Computer tomography of the lung under sevoflurane anaesthesia before and after dexmedetomidine was performed. Two minutes after dexmedetomidine mean pulmonary artery pressure, pulmonary arterial occlusion pressure and estimated capillary pressurewere significantly increased to 34.5mmHg, 22.2mmHg and 27.1mmHg, respectively. On computer tomography, lung density increased immediately after dexmedetomidine, with maximal density occurring between 9 and 12min. Histopathology was consistent with vascular congestion followed by protein and erythrocyte extravasation into alveoli. Increased iNOS mRNA levels were detected in sevoflurane anaesthetized animals only. An IL-1beta signal occurred after morphological changes had occurred in lung tissue. These findings support hydrostatic stress as the underlying cause of alpha(2) agonist-induced pulmonary oedema in sheep.
S B R Kästner; S Ohlerth; A Pospischil; J Boller; M K Huhtinen
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Publication Detail:
Type:  Journal Article     Date:  2007-01-16
Journal Detail:
Title:  Research in veterinary science     Volume:  83     ISSN:  0034-5288     ISO Abbreviation:  Res. Vet. Sci.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-07-02     Completed Date:  2007-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  217-26     Citation Subset:  IM    
Equine Hospital, Section of Veterinary Anaesthesia, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, CH-8057 Zurich, Switzerland.
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MeSH Terms
Adrenergic alpha-Agonists / adverse effects*
Analgesics, Non-Narcotic / adverse effects*
Blood Pressure / drug effects
Dexmedetomidine / adverse effects*
Inflammation / chemically induced,  veterinary
Lung / pathology
Nitric Oxide
Oxygen / blood
Polymerase Chain Reaction
Pulmonary Edema / chemically induced,  veterinary*
Sheep Diseases / chemically induced*
Vasoconstriction / drug effects
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Analgesics, Non-Narcotic; 10102-43-9/Nitric Oxide; 113775-47-6/Dexmedetomidine; 363-24-6/Dinoprostone; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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