| Dexmedetomidine as an adjunct to anesthetic induction to attenuate hemodynamic response to endotracheal intubation in patients undergoing fast-track CABG. | |
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MedLine Citation:
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PMID: 20075530 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During induction of general anesthesia hypertension and tachycardia caused by tracheal intubation may lead to cardiac ischemia and arrhythmias. In this prospective, randomized study, dexmedetomidine has been used to attenuate the hemodynamic response to endotracheal intubation with low dose fentanyl and etomidate in patients undergoing myocardial revascularization receiving beta blocker treatment. Thirty patients undergoing myocardial revascularization received in a double blind manner, either a saline placebo or a dexmedetomidine infusion (1 microg/kg) before the anesthesia induction. Heart rate (HR) and blood pressure (BP) were monitored at baseline, after placebo or dexmedetomidine infusion, after induction of general anesthesia, one, three and five minutes after endotracheal intubation. In the dexmedetomidine (DEX) group systolic (SAP), diastolic (DAP) and mean arterial pressures (MAP) were lower at all times in comparison to baseline values; in the placebo (PLA) group SAP, DAP and MAP decreased after the induction of general anesthesia and five minutes after the intubation compared to baseline values. This decrease was not significantly different between the groups. After the induction of general anesthesia, the drop in HR was higher in DEX group compared to PLA group. One minute after endotracheal intubation, HR significantly increased in PLA group while, it decreased in the DEX group. The incidence of tachycardia, hypotension and bradycardia was not different between the groups. The incidence of hypertension requiring treatment was significantly greater in the PLA group. It is concluded that dexmedetomidine can safely be used to attenuate the hemodynamic response to endotracheal intubation in patients undergoing myocardial revascularization receiving beta blockers. |
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Authors:
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Ferdi Menda; Ozge K?ner; Murat Sayin; Hatice T?re; Pinar Imer; Bora Ayka? |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Annals of cardiac anaesthesia Volume: 13 ISSN: 0974-5181 ISO Abbreviation: Ann Card Anaesth Publication Date: 2010 Jan-Apr |
Date Detail:
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Created Date: 2010-01-15 Completed Date: 2010-02-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9815987 Medline TA: Ann Card Anaesth Country: India |
Other Details:
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Languages: eng Pagination: 16-21 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Yeditepe University, Kozyata?i, Istanbul, Turkiye. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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pharmacology* Adult Aged Blood Pressure / drug effects Coronary Artery Bypass* Dexmedetomidine / pharmacology* Double-Blind Method Female Heart Rate / drug effects Hemodynamics / drug effects* Humans Intubation, Intratracheal* Male Middle Aged Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 113775-47-6/Dexmedetomidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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