Document Detail


Dexamethasone therapy interferes with the development of the neutrophil oxidative burst in vitro in very low birthweight infants.
MedLine Citation:
PMID:  17447193     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dexamethasone therapy is used in the treatment of chronic lung disease in very low birthweight (VLBW) neonates. However, several significant side effects have been observed in these patients, including an increased incidence of infection. We initiated a pilot study to examine the in vitro function of neutrophils from dexamethasone-treated VLBW infants. Following a 1-week course of dexamethasone, VLBW infants failed to demonstrate the increased oxidative burst that was observed in the age- and weight-matched untreated infants. These observations support recent evidence raising concern about effects on other organs when using dexamethasone in mechanically ventilated infants. In this example, impaired oxidative burst may be among the cellular factors contributing to the increased risk of infection during corticosteroid use in VLBW neonates in the neonatal intensive care setting.
Authors:
Magdy Ahmad; Howard B Fleit; Marc G Golightly; Edmund F La Gamma
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  24     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-07-27     Completed Date:  2007-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  223-5     Citation Subset:  IM    
Affiliation:
Division of Neonatal Medicine, Pediatrix Medical Group, Ohio, USA.
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MeSH Terms
Descriptor/Qualifier:
Anti-Inflammatory Agents / adverse effects*
Dexamethasone / adverse effects*
Female
Flow Cytometry
Humans
Infant, Newborn
Infant, Very Low Birth Weight / blood*
Male
Neutrophils / drug effects*,  physiology
Pilot Projects
Respiratory Burst / drug effects*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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