Document Detail

Dexamethasone therapy in bacterial meningitis.
MedLine Citation:
PMID:  8196985     Owner:  NLM     Status:  MEDLINE    
With improved understanding of the pathophysiology of bacterial meningitis, a number of points in the deleterious inflammatory cascade have been identified as possible sites for modulation. Dexamethasone attenuates tissue injury by inhibiting host mediators at several steps in the inflammatory process. Dexamethasone therapy initiated just before or simultaneously with the first parenteral antibiotic dose is recommended for infants older than 6 weeks of age and children with bacterial meningitis. A beneficial effect of steroid therapy administered 12 to 24 hours or more after the first dose of parenteral antibiotics is unlikely. The consistent finding of improved overall neurologic outcome in infants and children with bacterial meningitis caused by the usual meningeal pathogens treated with dexamethasone is the basis for this recommendation, provided that the caveats discussed above are observed.
H S Jafari; G H McCracken
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pediatric annals     Volume:  23     ISSN:  0090-4481     ISO Abbreviation:  Pediatr Ann     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-28     Completed Date:  1994-06-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0356657     Medline TA:  Pediatr Ann     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  82-8     Citation Subset:  IM    
Department of Pediatrics, University of Texas Southwestern Medical School, Dallas 75235-9063.
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MeSH Terms
Anti-Bacterial Agents / administration & dosage
Child, Preschool
Cytokines / metabolism
Dexamethasone / administration & dosage*,  pharmacology
Dinoprostone / metabolism
Drug Therapy, Combination
Endotoxins / metabolism
Infant, Newborn
Infusions, Intravenous
Meningitis, Bacterial / drug therapy*,  metabolism,  physiopathology
Platelet Activating Factor / metabolism
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Cytokines; 0/Endotoxins; 0/Platelet Activating Factor; 363-24-6/Dinoprostone; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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