| Dexamethasone suppression test and response to antidepressant therapy in psychogeriatric patients. | |
| | |
MedLine Citation:
|
PMID: 3407439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Senile dementia patients show a high incidence of abnormal Dexamethasone Suppression Test (DST) which has been suggested to reflect the presence of atypical or subclinical depression; this study was designed to test this hypothesis. Thirty-six patients, diagnosed as suffering from dementia and/or depression on the DSM-III criteria, participated in the study. They were divided into three groups. dementia (12), depression (12) and dementia with depression (12). The results indicated that although patients with depression alone responded well to antidepressant therapy, no improvement occurred in patients with dementia. Demented patients who had clinical depression also showed a poor response. The response to treatment was unrelated to the DST status of the patients. It is concluded that abnormal DST in dementia patients is not indicative of a masked affective state, and antidepressants have no place in the management of dementia patients who have a positive DST but no overt affective symptoms. |
| | |
Authors:
|
J Shrimankar; S D Soni; G Sampath |
Related Documents
:
|
12404649 - Improving clinical descriptions to understand the effects of dementia treatment: consen... 20047249 - Anxiety, depression, and cognitive impairment in dementia-specific and traditional assi... 12420649 - Cognitive pharmacotherapy of alzheimer's disease and other dementias. 17895439 - Effects of community occupational therapy on quality of life, mood, and health status i... 9771829 - Alzheimer's disease management. 2388639 - A controlled trial of piracetam in intellectually impaired patients with parkinson's di... 16095179 - Efficacy of azithromycin dihydrate in treatment of cryptosporidiosis in naturally infec... 20500119 - Perceived symptoms of psychological distress and salivary cortisol levels in young wome... 16356259 - Conflicting clinical trial data: a lesson from albumin. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta psychiatrica Scandinavica Volume: 77 ISSN: 0001-690X ISO Abbreviation: Acta Psychiatr Scand Publication Date: 1988 Jun |
Date Detail:
|
Created Date: 1988-09-22 Completed Date: 1988-09-22 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0370364 Medline TA: Acta Psychiatr Scand Country: DENMARK |
Other Details:
|
Languages: eng Pagination: 712-8 Citation Subset: IM |
Affiliation:
|
Psychiatric Research Unit, Prestwich Hospital, Manchester, England. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Amitriptyline / therapeutic use* Dementia / blood, diagnosis*, drug therapy Depressive Disorder / blood, diagnosis*, drug therapy Dexamethasone / diagnostic use* Female Humans Hydrocortisone / blood* Male Prognosis Psychiatric Status Rating Scales |
| Chemical | |
Reg. No./Substance:
|
50-02-2/Dexamethasone; 50-23-7/Hydrocortisone; 50-48-6/Amitriptyline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anxiety disorders and neuroticism: are there genetic factors specific to panic?
Next Document: Insulin-like growth factors and somatomedin B in the cerebrospinal fluid of patients with dementia o...