Document Detail

Dexamethasone reduces food intake, weight gain and the hypothalamic 5-HT concentration and increases plasma leptin in rats.
MedLine Citation:
PMID:  18164702     Owner:  NLM     Status:  MEDLINE    
This study was conducted to define the regulatory mechanisms underlying stress-induced decreases in food intake and weight gain. Rats received a single or 4 daily injections of dexamethasone (0.1 or 1 mg/kg). Food intake and weight gain were recorded, and plasma leptin, brain contents of serotonin (5-hydroxytryptamine; 5-HT), 5-hydroxy-indole-acetic acid (5-HIAA) and the raphe expression of tryptophan hydroxylase (TPH), monoamine oxidase A (MAO-A) and 5-HT reuptake transporter (5-HTT) genes were examined. A single injection of dexamethasone did not acutely affect food intake, but cumulative food intake and weight gain were suppressed dose-dependently by daily injections of dexamethasone. Both a single and repeated injections of dexamethasone elevated plasma leptin in a dose dependent manner. 5-HT contents in the hypothalamus was decreased, but 5-HIAA increased, both by a single and repeated dexamethasone. A single injection of dexamethasone did not affect mRNA expressions of TPH, MAO-A and 5-HTT genes, but repeated dexamethasone increased them in the dorsal raphe nucleus. These results suggest that plasma leptin may play a role in dexamethasone-induced anorexia. Additionally, increased expression of MAO-A and 5-HTT genes by repeated dexamethasone appears to be implicated in decreases of the brain 5-HT contents.
Jeong Won Jahng; Nam Youl Kim; Vitaly Ryu; Sang Bae Yoo; Bom-Taeck Kim; Dong-Won Kang; Jong-Ho Lee
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-24
Journal Detail:
Title:  European journal of pharmacology     Volume:  581     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-04     Completed Date:  2008-05-23     Revised Date:  2008-06-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  64-70     Citation Subset:  IM    
Dental Research Institute, Department of Oral and Maxillofacial Surgery, Seoul National University School of Dentistry, Seoul, 110-744, South Korea.
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MeSH Terms
Dexamethasone / pharmacology*
Dose-Response Relationship, Drug
Eating / drug effects*
Hydroxyindoleacetic Acid / analysis
Hypothalamus / chemistry*
Leptin / blood*
Monoamine Oxidase / genetics
RNA, Messenger / analysis
Rats, Sprague-Dawley
Receptors, Serotonin / physiology
Serotonin / analysis*
Serotonin Plasma Membrane Transport Proteins / genetics
Tryptophan Hydroxylase / genetics
Weight Gain / drug effects*
Reg. No./Substance:
0/Leptin; 0/RNA, Messenger; 0/Receptors, Serotonin; 0/Serotonin Plasma Membrane Transport Proteins; 50-02-2/Dexamethasone; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid; EC Hydroxylase; EC Oxidase

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