Document Detail


Dexamethasone intravitreal implant (Ozurdex) for the treatment of pediatric uveitis.
MedLine Citation:
PMID:  24698604     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
PURPOSE: To report our experience using Ozurdex (Allergan, Irvine, CA), a biodegradable intravitreal implant containing of 0.7 mg of dexamethasone approved for use in adults with noninfectious uveitis in adults, in the treatment of pediatric uveitis.
METHODS: The medical records of consecutive patients with noninfectious posterior uveitis who were unresponsive to standard treatment and subsequently received the Ozurdex implant from March 2011 to March 2013 were retrospectively reviewed.
RESULTS: A total of 14 eyes of 11 patients (mean age, 10.1 years; range 4-12) received 22 Ozurdex implants during the study period. Of the 11 patients, 7 had idiopathic intermediate or posterior uveitis, 1 had sympathetic ophthalmia, 2 had juvenile idiopathic arthritis, and 1 had sarcoidosis. All patients were uncontrolled with standard treatment, including topical or sub-Tenon's or systemic corticosteriods and/or immune-modulation. Visual acuity improved after Ozurdex implant in 5 of 8 patients (63%). Intraocular inflammation was controlled or improved after 17 of 22 of implants (12 eyes [77%]). The frequency of topical corticosteroids was decreased and/or discontinued after 18 of 22 implants (12 eyes [82%]). Complications included implant migration into the anterior chamber (4 aphakic eyes), increased intraocular pressure (5 eyes), and progression of a preexisting cataract (1 eye). The uveitis reoccurred in 57% of eyes at 4.3 months (2-7 months) after injection.
CONCLUSIONS: The Ozurdex implant in combination with systemic immunomodulatory therapy resulted in improved visual acuity, control of intraocular inflammation, and a decrease in corticosteroid use. In the majority of eyes the uveitis reoccurred around 4 months after injection. The adverse events in our study are similar to those identified in adult studies.
Authors:
Monica L Bratton; Yu-Guang He; David R Weakley
Related Documents :
24187354 - The short stem: promises and pitfalls.
23813844 - A systematic review on the safety and efficacy of percutaneous edge-to-edge mitral valv...
24947104 - Parallel transmit pulse design for patients with deep brain stimulation implants.
24835414 - Tissue stability of implants placed in fresh extraction sockets: a 5-year prospective s...
9477794 - The effectiveness of three irrigating solutions on root canal cleaning after hand and m...
20958284 - Improved procedure for implanting radiotransmitters in the coelomic cavity of snakes.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus     Volume:  18     ISSN:  1528-3933     ISO Abbreviation:  J AAPOS     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-04-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9710011     Medline TA:  J AAPOS     Country:  United States    
Other Details:
Languages:  eng     Pagination:  110-3     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 American Association for Pediatric Ophthalmology and Strabismus. Published by Mosby, Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Improvement in specific function-related quality-of-life concerns after strabismus surgery in nondip...
Next Document:  Predicting the need for laser treatment in retinopathy of prematurity using computer-assisted quanti...