| Dexamethasone inhibits platelet activating factor-induced inflammation in the paw but not the pleural cavity of rats. | |
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MedLine Citation:
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PMID: 3136026 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of drugs upon the inflammatory responses occurring after injection of 1 microgram platelet activating factor into the foot-pad and pleural cavity of the rat were investigated. Dexamethasone, but not indomethacin, BW755C, mepyramine or methysergide inhibited development of paw oedema; none of these drugs were effective in the pleurisy model. The triazolobenzodiazepine derivative WEB 2086 inhibited responses in both models. We conclude that the development of oedema in response to platelet activating factor in the rat is not dependent upon eicosanoid synthesis; and possible reasons for the difference in steroid sensitivity between the two sites are discussed. |
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Authors:
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S H Peers |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 150 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1988 May |
Date Detail:
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Created Date: 1988-09-16 Completed Date: 1988-09-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 131-5 Citation Subset: IM |
Affiliation:
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Pharmacology Group, University of Bath, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine Animals Dexamethasone / pharmacology* Edema / chemically induced Female Foot / pathology Indomethacin / pharmacology Inflammation / chemically induced* Male Platelet Activating Factor / antagonists & inhibitors* Pleura / pathology Pyrazoles / pharmacology Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Platelet Activating Factor; 0/Pyrazoles; 50-02-2/Dexamethasone; 53-86-1/Indomethacin; 66000-40-6/4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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