| Dexamethasone increases follicle-stimulating hormone secretion via suppression of inhibin in rats. | |
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MedLine Citation:
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PMID: 10611465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study, the effects of dexamethasone on follicle-stimulating hormone (FSH) secretion in immature female rats were investigated. Dexamethasone increased the selective secretion of FSH and decreased plasma concentrations of inhibin in immature female rats. The effects of dexamethasone on FSH secretion were not confirmed in rats treated with ovariectomy or immunoneutralization against inhibin. In addition to the direct effect of dexamethasone on FSH synthesis in gonadotrophs, the present study has clearly demonstrated that the increased level of FSH in dexamethasone-treated rats is mediated by suppression of ovarian function, especially by the inhibition of inhibin secretion. |
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Authors:
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A Tohei; H Kogo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 386 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1999 Dec |
Date Detail:
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Created Date: 2000-02-11 Completed Date: 2000-02-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 69-74 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dexamethasone / pharmacology* Estradiol / metabolism Female Follicle Stimulating Hormone / blood, secretion* Glucocorticoids / pharmacology* Gonadotropins / metabolism Inhibins / antagonists & inhibitors*, immunology Ovariectomy Radioimmunoassay Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Gonadotropins; 50-02-2/Dexamethasone; 50-28-2/Estradiol; 57285-09-3/Inhibins; 9002-68-0/Follicle Stimulating Hormone |
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