Document Detail


Dexamethasone in unexplained infertility.
MedLine Citation:
PMID:  19668883     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine if dexamethasone could be a suitable option in the treatment of patients with unexplained infertility. METHODS: This study was carried out in the Obstetrics Department of Amir University Hospital, Semnan, Iran, from April 2001 to May 2008. One hundred and twenty-four cases of unexplained infertility that underwent ovulation induction and intrauterine insemination (IUI) (only one cycle) were evaluated, and divided into 2 groups. Sixteen cases were excluded, as they were unresponsive to the induction ovulation regimen. Group I (n=42) received clomiphene citrate (CC) + dexamethasone, and the control group (group II, n=66) received CC alone. These groups were the same in age, duration of infertility, and body mass index. The clinical pregnancy rates were evaluated in 2 groups by using statistical tests. RESULTS: The clinical pregnancy rate was 21.4% in group I, and 4.5% in group II. There was a significant statistical difference between the groups (relative risk=4.71, 95% confidence interval=1.35-16.42, p=0.0085). CONCLUSION: The pregnancy rate in women with unexplained infertility that underwent ovulation induction with CC + dexamethasone + IUI was significantly higher than those who underwent ovulation induction with CC alone + IUI.
Authors:
Sanam Moradan; Raheb Ghorbani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Saudi medical journal     Volume:  30     ISSN:  0379-5284     ISO Abbreviation:  Saudi Med J     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-11     Completed Date:  2009-12-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909441     Medline TA:  Saudi Med J     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  1034-6     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Amir Hospital, Semnan, Iran. sm42595@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Clomiphene / therapeutic use
Dexamethasone / therapeutic use*
Drug Therapy, Combination
Female
Fertility Agents, Female / therapeutic use
Humans
Infertility, Female / drug therapy*
Insemination, Artificial
Ovulation / drug effects
Ovulation Induction / methods*
Pregnancy
Pregnancy Rate
Chemical
Reg. No./Substance:
0/Fertility Agents, Female; 50-02-2/Dexamethasone; 911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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