Document Detail


Dexamethasone as an adjuvant therapy for anovulatory, normoandrogenic patients during ovulation induction with exogenous gonadotropins.
MedLine Citation:
PMID:  8897119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The objective of our study was to explore the effect of dexamethasone (DEX), a highly potent, long-acting glucocorticoid, on the treatment outcome of 74 anovulatory women aged 21 to 29 years, with normal gonadotropins, androgen, and prolactin (PRL) serum levels who failed to conceive on antiestrogen therapy. METHODS: The patients received human menopausal gonadotropin/human chorionic gonadotropin (hMG/hCG) for ovulation induction. Starting on day 4 of the induced menstruation, hMG was administered in combination with DEX, 0.5 mg at night, or without DEX as an adjuvant treatment. The total amount of gonadotropins used, time required for stimulation, percentage of fertilization, serum estradiol levels, pregnancy rate, cumulative pregnancy rate, and abortions were recorded. RESULTS: There were no differences in either the cumulative pregnancy rate (54.1% in the DEX group and 52.7% in the untreated group) or the abortion rates (21.7% in the DEX group compared to 20.8% in the untreated group). The other parameters investigated also did not differ significantly between the groups. CONCLUSIONS: The overall results did not support DEX as a clinically useful adjuvant therapy for anovulatory, normoandrogenic patients.
Authors:
D Bider; Y Menashe; M Goldenberg; M Dulitzky; A Lifshitz; J Dor
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  13     ISSN:  1058-0468     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-03-11     Completed Date:  1997-03-11     Revised Date:  2008-03-18    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  613-6     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / epidemiology
Adrenal Cortex / drug effects
Adult
Androgens / blood
Anovulation / drug therapy*
Chemotherapy, Adjuvant
Chorionic Gonadotropin / administration & dosage,  therapeutic use*
Dexamethasone / administration & dosage,  pharmacology,  therapeutic use*
Drug Therapy, Combination
Estradiol / blood
Female
Fertility Agents, Female / therapeutic use*
Gonadotropins, Pituitary / blood
Humans
Menotropins / administration & dosage,  therapeutic use*
Ovulation Induction*
Pregnancy
Pregnancy Rate
Pregnancy, Multiple / statistics & numerical data
Prolactin / blood
Treatment Failure
Chemical
Reg. No./Substance:
0/Androgens; 0/Chorionic Gonadotropin; 0/Fertility Agents, Female; 0/Gonadotropins, Pituitary; 50-02-2/Dexamethasone; 50-28-2/Estradiol; 61489-71-2/Menotropins; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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