Document Detail


Dexamethasone alters glucose, lactate, and insulin dyshomeostasis during endotoxicosis in the rat.
MedLine Citation:
PMID:  3297379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examined the effects of dexamethasone on the glucose, lactate, and insulin dyshomeostasis of endotoxicosis in the rat. To assess the effects of dexamethasone on carbohydrate dyshomeostasis, sequential measurements of plasma glucose and lactate were made in vivo. The effects of dexamethasone on endotoxin-induced portal and systemic hyperinsulinemia also were evaluated in vivo. The ability of dexamethasone to alter the insulin hypersecretory state of the endotoxic pancreas was evaluated by using the in vitro perfused rat pancreas. Endotoxicosis caused severe hypoglycemia and hyperlactacidemia in the pentobarbital-anesthetized rat. Dexamethasone prevented the hypoglycemia, significantly reduced the hyperlactacidemia, and prevented endotoxin-induced hyperinsulinemia in vivo. Dexamethasone reduced endotoxin-induced pancreatic hypersecretion of insulin when administered as a pretreatment 1 h prior to endotoxin treatment; however, when administered as a cotreatment with endotoxin, no significant reduction of insulin hypersecretion occurred. The results of this study suggest that the ameliorating effects of dexamethasone on glucose and lactate dyshomeostasis occur not only at the peripheral tissue level, but also through effects on insulin secretion.
Authors:
M R Yelich; H S Havdala; J P Filkins
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulatory shock     Volume:  22     ISSN:  0092-6213     ISO Abbreviation:  Circ. Shock     Publication Date:  1987  
Date Detail:
Created Date:  1987-07-29     Completed Date:  1987-07-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0414112     Medline TA:  Circ Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  155-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / metabolism*
Dexamethasone / pharmacology*
Insulin / blood*
Lactates / blood*
Lactic Acid
Male
Pancreas / drug effects,  secretion
Rats
Rats, Inbred Strains
Shock, Septic / blood*
Grant Support
ID/Acronym/Agency:
DK-36044/DK/NIDDK NIH HHS; HL-31163/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Lactates; 11061-68-0/Insulin; 50-02-2/Dexamethasone; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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