Document Detail

Devices for noninvasive transcranial electrostimulation of the brain endorphinergic system: application for improvement of human psycho-physiological status.
MedLine Citation:
PMID:  11940025     Owner:  NLM     Status:  MEDLINE    
It is well known that deficit of endorphins plays an important role in disturbances of human psycho-physiological status. Previously, we revealed that brain endorphinergic structures have quasiresonance characteristics. On the basis of these data, a method of activation of the brain endorphinergic structures by means of noninvasive and rather selective transcranial electrostimulation (TES) as a kind of functional electrical stimulation (FES) was elaborated. New models of TES devices (TRANSAIR) were developed for indoor and outdoor usage. To increase the efficacy of TES, the frequency modulation according to normal distribution in the limits of the quasiresonance characteristics was put into operation. The blind and placebo-controlled (passive and active placebo) study was produced to estimate the TES effects on stress events and accompanied psycho-physiological and autonomic disturbances of different intensities on volunteers and patients in the following groups: everyday stress and fatigue; stress in regular military service and in field conditions; stress in the relatives of those lost in mass disaster; posttraumatic stress (thermal burns); and affective disorders in a postabstinence period. Some subjective verbal and nonverbal tests and objective tests (including heart rate variability) were used for estimation of the initial level of psycho-physiological status, which changes after TES sessions. It was demonstrated that fatigue, stress, and other accompanied psycho-physiological disturbances were significantly improved or abolished after 2-5 TES sessions. The TES effects were more pronounced in cases of heavier disturbances. In conclusion, activation of the brain endorphinergic structures by TES is an effective homeostatic method of FES that sufficiently improves quality of life.
Valery P Lebedev; A V Malygin; A V Kovalevski; S V Rychkova; V N Sisoev; S P Kropotov; E M Krupitski; L I Gerasimova; D V Glukhov; G P Kozlowski
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Artificial organs     Volume:  26     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-04-09     Completed Date:  2002-05-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  248-51     Citation Subset:  IM    
Pavlov Institute of Physiology, Military Medical Academy, and Regional Narcological Dispensary, Saint Petersburg, Russia.
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MeSH Terms
Brain / physiology*
Electric Stimulation / instrumentation*,  methods
Electric Stimulation Therapy / instrumentation*,  methods
Endorphins / physiology*
Equipment Design
Psychophysiologic Disorders / etiology,  therapy*
Treatment Outcome
Reg. No./Substance:

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