| Device for continuous extracorporeal blood purification using target-specific metal nanomagnets. | |
| | |
MedLine Citation:
|
PMID: 21310738 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: The present work illustrates how magnetic separation-based blood purification using ultra-strong iron nanomagnets can be implemented into an extracorporeal blood purification circuit. By this promising technique, today's blood purification may be extended to specifically filter high-molecular compounds without being limited by filter cut-offs or column surface saturation. METHODS: Blood spiked with digoxin (small molecule drug) and interleukin-1β (inflammatory protein) was circulated ex vivo through a device composed of approved blood transfusion lines. Target-specific nanomagnets were continuously injected and subsequently recovered with the aid of a magnetic separator before recirculating the blood. RESULTS: Magnetic blood purification was successfully carried out under flow conditions: already in single-pass experiments, removal efficiencies reached values of 75 and 40% for digoxin and interleukin-1β, respectively. Circulating 0.5 L of digoxin-intoxicated blood in a closed loop, digoxin concentration was decreased from initially toxic to therapeutic concentrations within 30 min and purification extents of 90% were achieved after 1.5 h. CONCLUSIONS: Magnetic separation can be successfully implemented into an extracorporeal blood purification device. Simultaneous and specific filtering of high-molecular compounds may offer promising new therapeutic tools for the future treatment of complex diseases, such as sepsis and autoimmune disorders. |
| | |
Authors:
|
Inge K Herrmann; Riccardo E Bernabei; Martin Urner; Robert N Grass; Beatrice Beck-Schimmer; Wendelin J Stark |
Related Documents
:
|
11419658 - The effect of priming techniques of ultrafiltrators on blood rheology: an in vitro eval... 16181878 - Cerebral physiology of cardiac surgical patients treated with the perfluorocarbon emuls... 8268578 - Development of an outside flow membrane oxygenator using a silicone hollow fiber. 7805248 - A new solution for life without blood. asanguineous low-flow perfusion of a whole-body ... 15265338 - Neurological conditions at altitude that fall outside the usual definition of altitude ... 9219468 - Clinical importance of measuring coronary graft flows in the revascularized heart. ultr... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-10 |
Journal Detail:
|
Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: - ISSN: 1460-2385 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-2-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, CH-8093 Zurich, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An extreme and life-threatening case of recurrent D-lactate encephalopathy.
Next Document: Combination of everolimus with calcineurin inhibitor medication resulted in post-transplant haemolyt...