Document Detail

Device closure of patent ductus arteriosus in Marfan patients: safety and effect on the aortic root diameter.
MedLine Citation:
PMID:  21087429     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: There is little evidence in the medical literature about safety of PDA device closure and its effects on aortic root diameter in Marfan patients. We reported on nine Marfan patients whose ducts were occluded by coil or Amplatzer Duct Occluder.
PATIENTS AND INTERVENTIONS: Two patients had aneurismal type E ducts which were closed by a single coil, respectively. The others had conical ducts for which even Amplatzer occluder, stiff, or double coils were used.
RESULTS: No untoward consequence was found during a median follow up period of 18.5 months (range 3 months to 6.33 years). Two patients had small residual shunts. The observed change in the mean ratio of aortic root diameter to its estimated value was statistically insignificant in seven patients who had complete data on their aortic root diameter before PDA closure and during the follow up.
CONCLUSIONS: We concluded that PDA device closure in Marfan patients is safe. Risk of residual shunt is higher even after closure of small ducts.
Keyhan S Zanjani; Abdul Rahim Wong; Masood Sadiq; Howard S Weber; Nancy G Cutler
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Congenital heart disease     Volume:  5     ISSN:  1747-0803     ISO Abbreviation:  Congenit Heart Dis     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-11-22     Completed Date:  2011-03-04     Revised Date:  2011-05-05    
Medline Journal Info:
Nlm Unique ID:  101256510     Medline TA:  Congenit Heart Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  439-43     Citation Subset:  IM    
Division of Pediatric Cardiology, Pediatric Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Child, Preschool
Ductus Arteriosus, Patent / complications,  therapy*,  ultrasonography
Heart Catheterization / adverse effects,  instrumentation*
Marfan Syndrome / complications*,  ultrasonography
Prosthesis Design
Risk Assessment
Septal Occluder Device*
Sinus of Valsalva / ultrasonography*
Time Factors
Treatment Outcome
United States
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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