| Device Therapy to Modulate the Autonomic Nervous System to Treat Heart Failure. | |
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MedLine Citation:
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PMID: 22833301 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Heart failure is the final common pathway in many forms of heart disease, and is associated with excessive morbidity and mortality. Pathophysiologic alterations in the interaction between the heart and the autonomic nervous system in advanced heart failure have been noted for decades. Over the last decade, great advances have been made in the medical and surgical treatment of heart failure - and some of these modalities target the neuro-cardiac axis. Despite these advances, many patients progress to end-stage heart failure and death. Recently, device-based therapy targeting the neuro-cardiac axis with various forms of neuromodulatory stimuli has been shown to improve heart function in experimental heart failure models. These include spinal cord stimulation, vagal nerve stimulation, and baroreflex modulation. Human trials are now underway to evaluate the safety and efficacy of these device-based neuromodulatory modalities in the heart failure population. |
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Authors:
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John C Lopshire; Douglas P Zipes |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-26 |
Journal Detail:
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Title: Current cardiology reports Volume: - ISSN: 1534-3170 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888969 Medline TA: Curr Cardiol Rep Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Krannert Institute of Cardiology, Indiana University School of Medicine, 1800 N Capitol Avenue, Suite E 310, Indianapolis, IN, 46202, USA, jlopshir@iupui.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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