Document Detail

Device-guided paced respiration as an adjunctive therapy for hypertension in obstructive sleep apnea: a pilot feasibility study.
MedLine Citation:
PMID:  21523471     Owner:  NLM     Status:  MEDLINE    
Data suggest that device-guided paced respiration (<10 breaths/min) may reduce blood pressure in hypertensive patients. We hypothesized that daily device-guided slow breathing may lower blood pressure in patients with hypertension and obstructive sleep apnea (OSA). In this one-arm pilot study, we enrolled 25 subjects with hypertension and OSA. Subjects were asked to perform device-guided paced respiration 30 min a day for 8 weeks. Our primary outcome was change in office systolic and diastolic blood pressures from baseline to 8 weeks. Twenty-four subjects completed the study. Mean baseline blood pressure was 140.0 ± 10.2 mmHg systolic and 82.7 ± 8.9 mmHg diastolic. Complete device data were available for 17 subjects. Mean device adherence was 81 ± 24% and 51% achieved a mean breath rate ≤10 breaths/min over 8 weeks. Three subjects had changes in their anti-hypertensive medications during the study. Among the remaining 21 subjects, mean difference in office blood pressure from baseline to 8 weeks was -9.6 ± 11.8 mmHg systolic (p ≤ 0.01) and -2.52 ± 8.9 mmHg diastolic (p = 0.21). Device-guided paced respiration may lower systolic blood pressure in patients with hypertension and OSA; however, our findings need to be confirmed with larger randomized controlled trials.
Suzanne M Bertisch; Ashley Schomer; Erin E Kelly; Leonardo A Baloa; Lauren E Hueser; Stephen D Pittman; Atul Malhotra
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Applied psychophysiology and biofeedback     Volume:  36     ISSN:  1573-3270     ISO Abbreviation:  Appl Psychophysiol Biofeedback     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-30     Completed Date:  2011-12-27     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  9712383     Medline TA:  Appl Psychophysiol Biofeedback     Country:  United States    
Other Details:
Languages:  eng     Pagination:  173-9     Citation Subset:  IM    
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MeSH Terms
Biofeedback, Psychology / methods*
Blood Pressure / physiology*
Feasibility Studies
Hypertension / complications,  physiopathology,  therapy*
Middle Aged
Pilot Projects
Sleep Apnea, Obstructive / complications,  physiopathology,  therapy*
Treatment Outcome
Grant Support
1 K23 AT005104-01/AT/NCCAM NIH HHS; K23 AT005104/AT/NCCAM NIH HHS; K23 AT005104-01/AT/NCCAM NIH HHS; K24 HL 093218/HL/NHLBI NIH HHS; K24 HL093218/HL/NHLBI NIH HHS; K24 HL093218-02/HL/NHLBI NIH HHS; R01 HL085188/HL/NHLBI NIH HHS; R01 HL085188-01/HL/NHLBI NIH HHS; R01 HL085188-01A2/HL/NHLBI NIH HHS; R01 HL090897/HL/NHLBI NIH HHS; R01 HL090897-01/HL/NHLBI NIH HHS; R01 HL090897-01A2/HL/NHLBI NIH HHS; R01 HL73146/HL/NHLBI NIH HHS; T32 AT000051/AT/NCCAM NIH HHS; T32 AT000051-06/AT/NCCAM NIH HHS; T32AT00051-06/AT/NCCAM NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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