Document Detail


Deviations in gait pattern in experimental models of hindlimb paresis shown by a novel pressure mapping system.
MedLine Citation:
PMID:  17539027     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Injuries to the central and peripheral nervous system result in varying degrees of paresis and as such alter gait. We developed novel quantitative measures to assess compensatory patterns of gait in experimental models of unilateral and bilateral hindlimb paresis. We hypothesized that hindlimb paresis results in unique alterations in the gait cycle that reflect the symmetry of the initial lesion. To test this hypothesis, adult, male Sprague-Dawley rats were subjected to a unilateral sciatic nerve crush injury or a moderately severe spinal cord contusion injury at T8. Kinematic and timing parameters were captured simultaneously in all four limbs and alterations in gait were then compared to relevant sham controls. Gait analysis consisted of walking trials through a gait tunnel positioned over a Tekscan pressure sensor grid. After sciatic nerve injury, animals unweighted the injured limb by shifting their center of mass toward the contralateral forelimb and hindlimb. These changes in weight-bearing occurred simultaneously with an increase in stance time on the contralateral limbs. As might be expected spinal cord injured animals unweighted their hindlimbs, as shown by reduced hindlimb contact force and contact pressure. These adjustments coincided with a shortening of forelimb stance time and stride length. These findings show both alterations and compensatory changes in gait that reflect the symmetry of the initial injury.
Authors:
Benjamin S Boyd; Christian Puttlitz; Linda J Noble-Haeusslein; Constance M John; Alpa Trivedi; Kimberly S Topp
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroscience research     Volume:  85     ISSN:  0360-4012     ISO Abbreviation:  J. Neurosci. Res.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-16     Completed Date:  2007-11-01     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  7600111     Medline TA:  J Neurosci Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2272-83     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley-Liss, Inc.
Affiliation:
Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, California 94143-0736, USA. Benjamin.Boyd@ucsfmedctr.org
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Animals
Biomechanics
Contusions / complications
Electrophysiology / instrumentation
Equipment Design
Forelimb / physiopathology
Gait*
Hindlimb*
Male
Nerve Crush
Paresis / etiology,  physiopathology*
Pressure
Rats
Rats, Sprague-Dawley
Sciatic Nerve / injuries
Spinal Cord Injuries / complications
Time Factors
Grant Support
ID/Acronym/Agency:
2 R44 HD042333-02/HD/NICHD NIH HHS; R01 NS39278/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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