Document Detail


Developmentally regulated expression of c-Fos and c-Jun in the brainstem auditory nuclei of Gallus domesticus is modified by prenatal auditory enrichment.
MedLine Citation:
PMID:  15389680     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recognition of mother's voice by human neonates and behavioral responses of birds and animals to sounds experienced prenatally emphasize the role of sensory inputs in auditory system development. Spontaneous and experience driven neural activity influence the neural circuits' refinement in developing brain. However, cellular mechanisms endowing plasticity for such structural refinement during critical developmental periods are less understood. Sensory stimulation induces fluctuating expression of transcription factors (TFs) of Fos, Jun, and Krox families in the related brain nuclei to activate genes to synthesize proteins such as those needed for cytoskeletal structures, ion channels, and regeneration. To understand the cellular mechanism of response to prenatal auditory stimulation, we studied the expression of c-Fos and c-Jun in brainstem auditory nuclei, nucleus magnocellularis, and nucleus laminaris of the domestic chick. The chick brainstems, five each of E8 (embryonic day 8), E12, E16, E20, and posthatch day 1 were processed for immunohistochemistry as well as Western blotting and quantified using image analysis systems. In controls, c-Fos and c-Jun expression in both the nuclei was developmentally up-regulated. Reduced c-Fos expression and increase in c-Jun was temporarily observed between E12-16. In the stimulated groups, c-Fos expression was elevated while c-Jun showed a reduction matched to controls. This diametrically opposing pattern of c-Fos and c-Jun expression in response to stimulation is indicative of cell survival. Thus the expression of TFs in the auditory nuclei shows a relationship beyond a simple stimulation-activity-expression. While developmental signals control the expression of TFs, extra sensory stimulation modulates their expression to possibly support neuronal survival and enhance synthesis of other proteins.
Authors:
Phalguni Anand Alladi; Tarashankar Roy; Neeta Singh; Shashi Wadhwa
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurobiology     Volume:  62     ISSN:  0022-3034     ISO Abbreviation:  J. Neurobiol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-07     Completed Date:  2005-05-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0213640     Medline TA:  J Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  92-105     Citation Subset:  IM    
Copyright Information:
(c) 2004 Wiley Periodicals, Inc.
Affiliation:
Department of Anatomy, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation / methods
Animals
Auditory Pathways / cytology,  growth & development*,  metabolism
Brain Stem / cytology,  growth & development*,  metabolism
Cell Survival / genetics
Chick Embryo
Chickens / anatomy & histology,  growth & development*,  metabolism
Cochlear Nucleus / cytology,  growth & development,  metabolism
Female
Gene Expression Regulation, Developmental / genetics,  physiology*
Genes, Immediate-Early / genetics
Neuronal Plasticity / genetics
Proto-Oncogene Proteins c-fos / metabolism*
Proto-Oncogene Proteins c-jun / metabolism*
Transcriptional Activation / genetics
Up-Regulation / genetics
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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