Document Detail

Developmental triclosan exposure decreases maternal and neonatal thyroxine in rats.
MedLine Citation:
PMID:  20954233     Owner:  NLM     Status:  In-Process    
Disruption of maternal thyroid hormones during fetal developmental may result in irreversible neurological consequences in offspring. The present study tested the hypothesis that perinatal triclosan exposure of dams decreases thyroxine in dams and offspring prior to weaning. Pregnant Long-Evans rats received triclosan by oral gavage (0-300 mg/kg/d) in corn oil from gestational day (GD)6 through postnatal day (PND)21. Serum was obtained from pups on PND4, 14, and 21, and from dams on PND22. Serum thyroxine (T4) was reduced 31% in dams on PND22. In pups, a unique pattern of hypothyroxinemia was observed; serum T4 decreased 27% in PND4 pups with no significant reduction observed on PND14 or PND21. Comparable reductions of approximately 30% in serum T4 at 300 mg/kg/d for dams and PND4 neonates and a lack of effect at PND14 and PND21 suggest that toxicokinetic or toxicodynamic factors may have contributed to a reduced exposure or a reduced toxicological response during the lactation period.
Katie B Paul; Joan M Hedge; Michael J Devito; Kevin M Crofton
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-10-15
Journal Detail:
Title:  Environmental toxicology and chemistry / SETAC     Volume:  29     ISSN:  1552-8618     ISO Abbreviation:  Environ. Toxicol. Chem.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308958     Medline TA:  Environ Toxicol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2840-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 SETAC.
University of North Carolina, Chapel Hill, North Carolina, USA.
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