| Developmental transitions in cardiac conduction. | |
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MedLine Citation:
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PMID: 12956324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The proper sequence of electrical activation of the mature four-chambered heart requires specialized conduction pathways including the His-Purkinje system and a nearly complete separation of the atrial and ventricular myocardium. We tracked the emergence of the structure of the mature His-Purkinje system in the developing chicken embryo with anti-polysialylated neural cell adhesion molecule (PSA-NCAM) and the HNK1 antibody against a sulfated carbohydrate epitope. The function of the His-Purkinje system was assayed using extracellular electrodes and high-resolution voltage-sensitive two-dimensional optical mapping. The appearance of the mature form of the His-Purkinje system delineated by the markers coincided with the onset of the mature electrophysiological pattern of ventricular activation. These data suggest that, at the completion of ventricular septation, the His-Purkinje system undergoes critical structural and functional transitions that impact on the global pattern of conduction and contraction of the developing four-chambered heart. |
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Authors:
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Michiko Watanabe; Emil Thomas Chuck; Florence Rothenberg; David S Rosenbaum |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Novartis Foundation symposium Volume: 250 ISSN: 1528-2511 ISO Abbreviation: Novartis Found. Symp. Publication Date: 2003 |
Date Detail:
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Created Date: 2003-09-05 Completed Date: 2004-04-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9807767 Medline TA: Novartis Found Symp Country: England |
Other Details:
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Languages: eng Pagination: 68-75; discussion 76-9, 276-9 Citation Subset: IM |
Affiliation:
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Division of Pediatric Cardiology, Department of Pediatrics, Rainbow Babies and Children's Hospital, 11100 Euclid Avenue, Cleveland, OH 44106, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials Animals Apoptosis Chick Embryo / anatomy & histology, physiology Electrocardiography Heart / anatomy & histology, growth & development* Heart Conduction System / growth & development*, physiology Myocardium / cytology, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HL0266/HL/NHLBI NIH HHS; HL38172/HL/NHLBI NIH HHS; HL54807/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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