Document Detail


Developmental toxicity studies in Crl:CD (SD) rats following inhalation exposure to trichloroethylene and perchloroethylene.
MedLine Citation:
PMID:  17066414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The potential for trichloroethylene (TCE) and perchloroethylene (PERC) to induce developmental toxicity was investigated in Crl:CD (SD) rats whole-body exposed to target concentrations of 0, 50, 150 or 600 ppm TCE or 0, 75, 250 or 600 ppm PERC for six hours/day, seven days/week on gestation day (GD) 6-20 and 6-19, respectively. Actual chamber concentrations were essentially identical to target with the exception of the low PERC exposure level, which was 65 ppm. The highest exposure levels exceeded the limit concentration (2 mg/L) specified in the applicable test guidelines. Maternal necropsies were performed the day following the last exposure. Dams exposed to 600 ppm TCE exhibited maternal toxicity, as evidenced by decreased body weight gain (22% less than control) during GD 6-9. There were no maternal effects at 50 or 150 ppm TCE and no indications of developmental toxicity (including heart defects or other terata) at any exposure level tested. Therefore, the TCE NOEC for maternal toxicity was 150 ppm, whereas the embryo/fetal NOEC was 600 ppm. Maternal responses to PERC were limited to slight, but statistically significant reductions in body weight gain and feed consumption during the first 3 days of exposure to 600 ppm, resulting in a maternal NOEC of 250 ppm. Developmental effects at 600 ppm consisted of reduced gravid uterus, placental and fetal body weights, and decreased ossification of thoracic vertebral centra. Developmental effects at 250 ppm were of minimal toxicological significance, being limited to minor decreases in fetal and placental weight. There were no developmental effects at 65 ppm.
Authors:
E W Carney; B A Thorsrud; P H Dugard; C L Zablotny
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Birth defects research. Part B, Developmental and reproductive toxicology     Volume:  77     ISSN:  1542-9733     ISO Abbreviation:  Birth Defects Res. B Dev. Reprod. Toxicol.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-31     Completed Date:  2007-04-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101155115     Medline TA:  Birth Defects Res B Dev Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  405-12     Citation Subset:  IM    
Affiliation:
Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674, USA. ecarney@dow.com
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced
Animals
Body Weight / drug effects
Embryonic Development / drug effects*
Female
Fetus / abnormalities,  drug effects,  embryology
Inhalation Exposure*
Maternal Exposure
Pregnancy
Rats
Rats, Sprague-Dawley
Tetrachloroethylene / administration & dosage,  toxicity*
Trichloroethylene / administration & dosage,  toxicity*
Weight Gain / drug effects
Chemical
Reg. No./Substance:
127-18-4/Tetrachloroethylene; 79-01-6/Trichloroethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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