| Developmental toxicity of methoxyflurane in mice. | |
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MedLine Citation:
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PMID: 7189979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The developmental toxicity of trace, subanesthetic, and anesthetic exposure to methoxyflurane was examined in Swiss/ICR mice. No adverse effects on reproduction or fetal development were demonstrated following exposure to trace (2 ppm) and subanesthetic (60 ppm) concentrations of methoxyflurane for 4 hours daily on days 6 through 15 of pregnancy. Exposure to an anesthetic concentration (2000 ppm; 0.2%) for the same period resulted in decreased fetal weight, decreased ossification, and delayed renal maturation. Additionally, the incidence of minor skeletal anomalies was increased. It is concluded that gestational exposure of mice to trace of subanesthetic concentrations of methoxyflurane does not result in reproductive loss or morphologic abnormalities in their offspring. |
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Authors:
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R S Wharton; T S Sievenpiper; R I Mazze |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 59 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 1980 Jun |
Date Detail:
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Created Date: 1980-08-25 Completed Date: 1980-08-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 421-5 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced Animals Body Weight / drug effects Female Fetal Viability / drug effects Fetus / drug effects* Kidney / drug effects Male Methoxyflurane / toxicity* Mice Osteogenesis / drug effects Pregnancy / drug effects* Skeleton / abnormalities |
| Chemical | |
Reg. No./Substance:
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76-38-0/Methoxyflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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