Document Detail


Developmental toxicity of guthion in rats and mice.
MedLine Citation:
PMID:  7369866     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to assess the effects of Guthion, a pesticide with anticholinesterase activity, on development in rats and mice. A preliminary toxicity study with Guthion indicated that a 35-day LD50 dose for virgin rats and a 10-day LD50 dose for virgin mice was between 4 and 8 mg/kg/day for both species. On the basis of these data, doses of 0, 1.25, 2.5, and 5.0 mg/kg/day were selected for the developmental study, which consisted of two phases. During the first phase, pregnant rats and mice were treated for 10 days starting on gestational day 6. The high dose affected maternal welfare only in rats. Guthion did not significantly increase in a dose-related manner any of the specific anomalies observed in either rats or mice. During the second phase, pregnant rats were treated from gestational day 6 to postpartum day 21. Dams in the high dose group were more sensitive to Guthion later in gestation with the result that deaths and signs of anticholinesterase toxicity increased during this time. Guthion also adversely affected maternal welfare in this group. As a result of Guthion toxicity, only one litter survived until weaning. The inability to dissociate toxicity in adult and developing animals suggests that Guthion has little primary effect on the development of rats or mice.
Authors:
R D Short; J L Minor; C C Lee; N Chernoff; R L Baron
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Archives of toxicology     Volume:  43     ISSN:  0340-5761     ISO Abbreviation:  Arch. Toxicol.     Publication Date:  1980 Jan 
Date Detail:
Created Date:  1980-06-16     Completed Date:  1980-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417615     Medline TA:  Arch Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  177-86     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / etiology
Animals
Azinphosmethyl / toxicity*
Bone and Bones / drug effects
Female
Fetus / drug effects
Insecticides / toxicity*
Lactation / drug effects
Lethal Dose 50
Mice
Pregnancy
Rats
Reproduction / drug effects
Species Specificity
Teratogens
Chemical
Reg. No./Substance:
0/Insecticides; 0/Teratogens; 86-50-0/Azinphosmethyl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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