Document Detail


Developmental toxicity of ethanol in chick heart in ovo and in micromass culture can be prevented by addition of vitamin C and folic acid.
MedLine Citation:
PMID:  19473809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The teratogenic effects of ethanol include malformations of the cardiovascular system, which may be abrogated by multivitamin therapy. Chick cardiomyocytes in micromass culture were treated with ethanol alone or with supplementation with folate or vitamin C. Ethanol alone caused a loss of cell viability and differentiation (beating) whereas those cells treated in addition with vitamins were comparable to the control. Chick embryos were injected on day 3 of incubation with PBS, ethanol alone or with additional vitamin C or folic acid. On day 9 embryos were examined for viability, growth retardation and gross malformation and the hearts were processed for histology. Results showed that ethanol significantly decreased survival of embryos or caused growth retardation and gross malformation (p<0.05). Embryos incubated with addition of vitamin C or folic acid were comparable to the control. Data obtained in this study suggest that supplementation with vitamin C or folic acid during pregnancy may prevent defects in heart development brought about by ethanol.
Authors:
Samreen Memon; Margaret K Pratten
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-10
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  28     ISSN:  1873-1708     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-07-27     Completed Date:  2009-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  262-9     Citation Subset:  IM    
Affiliation:
Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen's Medical Centre, University of Nottingham NG7 2UH, UK. mbxsm4@nottingham.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / prevention & control*
Animals
Ascorbic Acid / pharmacology*
Cell Survival / drug effects
Cells, Cultured
Chick Embryo
Drug Antagonism
Embryo Loss / chemically induced
Ethanol / toxicity*
Fetal Weight / drug effects
Folic Acid / pharmacology*
Heart / drug effects*,  embryology
Heart Defects, Congenital / chemically induced,  pathology
Myocytes, Cardiac / drug effects*,  pathology
Chemical
Reg. No./Substance:
50-81-7/Ascorbic Acid; 59-30-3/Folic Acid; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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