| Developmental toxicity of ethanol in chick heart in ovo and in micromass culture can be prevented by addition of vitamin C and folic acid. | |
| | |
MedLine Citation:
|
PMID: 19473809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The teratogenic effects of ethanol include malformations of the cardiovascular system, which may be abrogated by multivitamin therapy. Chick cardiomyocytes in micromass culture were treated with ethanol alone or with supplementation with folate or vitamin C. Ethanol alone caused a loss of cell viability and differentiation (beating) whereas those cells treated in addition with vitamins were comparable to the control. Chick embryos were injected on day 3 of incubation with PBS, ethanol alone or with additional vitamin C or folic acid. On day 9 embryos were examined for viability, growth retardation and gross malformation and the hearts were processed for histology. Results showed that ethanol significantly decreased survival of embryos or caused growth retardation and gross malformation (p<0.05). Embryos incubated with addition of vitamin C or folic acid were comparable to the control. Data obtained in this study suggest that supplementation with vitamin C or folic acid during pregnancy may prevent defects in heart development brought about by ethanol. |
| | |
Authors:
|
Samreen Memon; Margaret K Pratten |
Related Documents
:
|
4053129 - Pantothenic acid deficiency as a factor contributing to the development of hypertension. 7844109 - The role of ascorbate in antioxidant protection of biomembranes: interaction with vitam... 11061189 - Effect of water-soluble vitamins on the production of indole-3-acetic acid by azospiril... 4737379 - Selective release of lysosomal hydrolases from phagocytic cells by cytochalasin b. 12894539 - Application of semiempirical method to estimate the cytotoxic activity of gallic acid a... 2634039 - Assay of pyridoxal-5'-phosphate, pyridoxal and pyridoxic acid in biological material. 155699 - A comparative study of poly(glycolic acid) and catgut as suture materials. histomorphol... 45009 - In vitro dimroth rearrangement of 1-(2-carboxyethyl) adenine to n6-(2-carboxyethyl)aden... 11142409 - Primary alcohols and di-alcohols as growth substrates for the purple nonsulfur bacteriu... |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-04-10 |
Journal Detail:
|
Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 28 ISSN: 1873-1708 ISO Abbreviation: Reprod. Toxicol. Publication Date: 2009 Sep |
Date Detail:
|
Created Date: 2009-07-27 Completed Date: 2009-09-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: United States |
Other Details:
|
Languages: eng Pagination: 262-9 Citation Subset: IM |
Affiliation:
|
Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen's Medical Centre, University of Nottingham NG7 2UH, UK. mbxsm4@nottingham.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abnormalities, Drug-Induced
/
prevention & control* Animals Ascorbic Acid / pharmacology* Cell Survival / drug effects Cells, Cultured Chick Embryo Drug Antagonism Embryo Loss / chemically induced Ethanol / toxicity* Fetal Weight / drug effects Folic Acid / pharmacology* Heart / drug effects*, embryology Heart Defects, Congenital / chemically induced, pathology Myocytes, Cardiac / drug effects*, pathology |
| Chemical | |
Reg. No./Substance:
|
50-81-7/Ascorbic Acid; 59-30-3/Folic Acid; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ischemic Optic Neuropathy After Hemiarthroplasty for Femoral Neck Fracture.
Next Document: Changing author counts in five major general medicine journals: effect of author contribution forms.