| Developmental toxicity of cypermethrin in embryo-larval stages of zebrafish. | |
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MedLine Citation:
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PMID: 21840035 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Cypermethrin, a type II pyrethroid insecticide, is widely used throughout the world in agriculture, forestry, horticulture and homes. Though the neurotoxicity of cypermethrin has been thoroughly studied in adult rodents, little is so far available regarding the developmental toxicity of cypermethrin to fish in early life stages. To explore the potential developmental toxicity of cypermethrin, 4-h post-fertilization (hpf) zebrafish embryos were exposed to various concentrations of cypermethrin (0, 25, 50, 100, 200 and 400μgL(-1)) until 96h. Among a suite of morphological abnormalities, the unique phenotype curvature was observed at concentrations as low as 25μgL(-1). Studies revealed that 400μgL(-1) cypermethrin significantly increased malondialdehyde production. In addition, activity of antioxidative enzymes including superoxide dismutase and catalase were significantly induced in zebrafish larvae in a concentration-dependent manner. To further investigate the toxic effects of cypermethrin on fish, acridine orange (AO) staining was performed at 400μgL(-1) cypermethrin and the result showed notable signs of apoptosis mainly in the nervous system. Cypermethrin also down-regulated ogg1 and increased p53 gene expression as well as the caspase-3 activity. Our results demonstrate that cypermethrin was able to induce oxidative stress and produce apoptosis through the involvement of caspases in zebrafish embryos. In this study, we investigated the developmental toxicity of cypermethrin using zebrafish embryos, which could be helpful in fully understanding the potential mechanisms of cypermethrin exposure during embryogenesis and also suggested that zebrafish could serve as an ideal model for studying developmental toxicity of environmental contaminants. |
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Authors:
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Xiangguo Shi; Aihua Gu; Guixiang Ji; Yuan Li; Jing Di; Jing Jin; Fan Hu; Yan Long; Yankai Xia; Chuncheng Lu; Ling Song; Shoulin Wang; Xinru Wang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-11 |
Journal Detail:
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Title: Chemosphere Volume: - ISSN: 1879-1298 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0320657 Medline TA: Chemosphere Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 210029, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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