Document Detail


Developmental toxicity of cocaine exposure in mid-pregnancy mice.
MedLine Citation:
PMID:  12421481     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To investigate the toxic effects of mid-pregnancy cocaine exposure on embryo-fetus. METHODS: A transplacental murine model of cocaine exposure on embryo-fetus mice was established, in which pregnant dams of comparable weight were assigned into three groups: cocaine with food ad lib (COC), saline and pair-fed with COC (SPF), and saline with food ad lib (SAL). From embryonic d 8 (E8) to E17, physiological variables of dams and offspring were recorded and concentrations of dopamine and serotonin in fetal striatum were examined. RESULTS: Compared with SAL dams, COC and SPF dams showed lower weight gain. But only COC fetuses demonstrated low brain weight and low striatum weight on E17, as well as small biparietal diameter (BPD) on postnatal d1 (P1). Surprisingly, low brain/body weight ratio was seen in COC offspring, which might reflect disproportionate growth delay in these fetuses. Neurotransmitter and histological analysis revealed high level of dopamine and serotonin in COC fetal striatum, as well as morphological alterations of liver. CONCLUSION: Mid-pregnancy cocaine exposure induces fetal growth delay in utero, especially disproportionate brain developmental retardation. Maternal undernutrition does not play a key role in fetal developmental retardation when exposed to cocaine in utero.
Authors:
Jun Song; Xiao-Wei Guan; Jia-Qian Ren; Wei He
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta pharmacologica Sinica     Volume:  23     ISSN:  1671-4083     ISO Abbreviation:  Acta Pharmacol. Sin.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-07     Completed Date:  2004-08-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100956087     Medline TA:  Acta Pharmacol Sin     Country:  China    
Other Details:
Languages:  eng     Pagination:  1029-34     Citation Subset:  IM    
Affiliation:
Department of Histology, Institute of Brain Research, China Medical University, Shenyang 110001, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Brain / drug effects*,  embryology,  metabolism
Cocaine / toxicity*
Corpus Striatum / embryology,  metabolism
Dopamine / metabolism
Embryonic and Fetal Development / drug effects*
Female
Fetal Weight / drug effects
Maternal-Fetal Exchange*
Mice
Organ Size / drug effects
Pregnancy
Prenatal Exposure Delayed Effects*
Serotonin / metabolism
Chemical
Reg. No./Substance:
50-36-2/Cocaine; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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