| Developmental toxicity of cocaine exposure in mid-pregnancy mice. | |
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MedLine Citation:
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PMID: 12421481 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To investigate the toxic effects of mid-pregnancy cocaine exposure on embryo-fetus. METHODS: A transplacental murine model of cocaine exposure on embryo-fetus mice was established, in which pregnant dams of comparable weight were assigned into three groups: cocaine with food ad lib (COC), saline and pair-fed with COC (SPF), and saline with food ad lib (SAL). From embryonic d 8 (E8) to E17, physiological variables of dams and offspring were recorded and concentrations of dopamine and serotonin in fetal striatum were examined. RESULTS: Compared with SAL dams, COC and SPF dams showed lower weight gain. But only COC fetuses demonstrated low brain weight and low striatum weight on E17, as well as small biparietal diameter (BPD) on postnatal d1 (P1). Surprisingly, low brain/body weight ratio was seen in COC offspring, which might reflect disproportionate growth delay in these fetuses. Neurotransmitter and histological analysis revealed high level of dopamine and serotonin in COC fetal striatum, as well as morphological alterations of liver. CONCLUSION: Mid-pregnancy cocaine exposure induces fetal growth delay in utero, especially disproportionate brain developmental retardation. Maternal undernutrition does not play a key role in fetal developmental retardation when exposed to cocaine in utero. |
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Authors:
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Jun Song; Xiao-Wei Guan; Jia-Qian Ren; Wei He |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta pharmacologica Sinica Volume: 23 ISSN: 1671-4083 ISO Abbreviation: Acta Pharmacol. Sin. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-11-07 Completed Date: 2004-08-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100956087 Medline TA: Acta Pharmacol Sin Country: China |
Other Details:
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Languages: eng Pagination: 1029-34 Citation Subset: IM |
Affiliation:
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Department of Histology, Institute of Brain Research, China Medical University, Shenyang 110001, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Brain / drug effects*, embryology, metabolism Cocaine / toxicity* Corpus Striatum / embryology, metabolism Dopamine / metabolism Embryonic and Fetal Development / drug effects* Female Fetal Weight / drug effects Maternal-Fetal Exchange* Mice Organ Size / drug effects Pregnancy Prenatal Exposure Delayed Effects* Serotonin / metabolism |
| Chemical | |
Reg. No./Substance:
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50-36-2/Cocaine; 50-67-9/Serotonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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