Document Detail

Developmental studies on glucosamine metabolism.
MedLine Citation:
PMID:  967894     Owner:  NLM     Status:  MEDLINE    
Changes in hepatic hexosamine metabolism and serum seromucoid concentrations during postnatal development were investigated in the rat. A relatively low activity of hepatic L-glutamine: D-fructose-6-phosphate aminotransferase (AT) was observed within 24 hr of birth. This rapidly increased to a maximum at about 2 weeks of age, followed by a decline to adult levels after another 2 weeks. The developmental pattern of hepatic UDP-N-acetylglucosamine 2'-epimerase (EP) closely resembled that of AT. It was relatively low in the newborn, increased to a maximum at about 2 weeks and then declined to adult values after another 2 weeks. The serum seromucoid concentration was low in the new born rats and then increased gradually with development to adult levels at about 50 days. The hepatic concentrations of UDP-GlcNAC and CMP-NANA both were relatively high at 24 hr after birth compared to values observed at 50 days. The developmental pattern observed for both over this time period was quite similar and was almost the reciprocal to that for the seromucoid fraction. After 50 days the concentration of UDP-GlcNAc remained constant at adult levels as did that of the seromucoid fraction, but the concentration of CMP-NANA showed a marked increase. It is suggested that the hepatic concentrations of these amino-sugar nucleotides during development primarily reflect the demand for the hepatic synthesis and secretion of plasma glycoproteins as reflected in the seromucoid fraction.
H Okubo; K Shibata; H Ishibashi; T Yanase
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)     Volume:  152     ISSN:  0037-9727     ISO Abbreviation:  Proc. Soc. Exp. Biol. Med.     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1976-11-21     Completed Date:  1976-11-21     Revised Date:  2007-11-02    
Medline Journal Info:
Nlm Unique ID:  7505892     Medline TA:  Proc Soc Exp Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  626-30     Citation Subset:  IM    
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MeSH Terms
Cytidine Monophosphate N-Acetylneuraminic Acid / metabolism
Glucosamine / metabolism*
Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / metabolism
Liver / enzymology*
Uridine Diphosphate N-Acetylglucosamine / metabolism
Reg. No./Substance:
3063-71-6/Cytidine Monophosphate N-Acetylneuraminic Acid; 3416-24-8/Glucosamine; 528-04-1/Uridine Diphosphate N-Acetylglucosamine; EC Transaminase (Isomerizing)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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