Document Detail


Developmental remodeling of the internal elastic lamina of rabbit arteries: effect of blood flow.
MedLine Citation:
PMID:  8620599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined remodeling of the internal elastic lamina (IEL) of rabbit arteries from 3 to 23 weeks of age. The IELs were fenestrated at all ages; however, the sizes of the fenestrae increased dramatically during postnatal development. Mean areas occupied by the individual fenestrae of the carotid artery IEL increased from 11.3 +/- 0.7 microns2 in 3-week-old rabbits to 61.2 +/- 5.5 microns2 in adult rabbits. The estimated number of fenestrae per vessel also increased greatly, from 2.68 x 10(5) to 9.27 x 10(5); however, the increased number of fenestrae did not keep pace with growth of the artery, since fenestrae per square millimeter decreased by 26%. Large increases in the size of fenestrae were also observed in the renal and iliac arteries, although greater decreases in fenestrae per square millimeter occurred with age (70% in iliac arteries). Morphological assessments suggested that enlarging fenestrae frequently fuse with neighbors. By contrast with other arteries, the IEL of the abdominal aorta was not a continuous fenestrated sheet in young animals, perhaps reflecting the extensive remodeling that this vessel undergoes in the postnatal period. We decreased common carotid blood flow by 70% in 5 rabbits at 10 weeks of age by ligating the ipsilateral external carotid artery, and we approximately doubled blood flow in 5 others at the same age, by contralateral common carotid ligation. At 15 weeks of age, fenestrae in the artery carrying increased flow were 39% larger than fenestrae in the control artery, whereas fenestrae were 53.5% smaller after 70% decreases in flow (P < .05). We conclude that flow-dependent enlargement of fenestrae contributes to developmental remodeling of the IEL. Remodeling of the IEL may also have important implications for transport of materials and cell-cell communication between the intima and media.
Authors:
L C Wong; B L Langille
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation research     Volume:  78     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-06-18     Completed Date:  1996-06-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  799-805     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Toronto, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries / anatomy & histology,  growth & development*,  physiology*
Carotid Arteries / growth & development
Elastic Tissue / anatomy & histology,  growth & development*,  physiology*
Microscopy, Confocal
Rabbits
Regional Blood Flow / physiology*
Stress, Mechanical

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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