Document Detail


Developmental regulation of regenerative specificity in the bullfrog.
MedLine Citation:
PMID:  8457898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The accuracy with which motor axons reinnervate the hindlimb following ventral rhizotomy was studied in the bullfrog (Rana catesbeiana) by mapping the locations within the lumbar lateral motor column of motoneurons retrogradely labeled with horseradish peroxidase. At early stages of development, axons regenerate to the correct hindlimb region. In older tadpoles and frogs, axons appear to regenerate to targets determined by basal lamina tubes, which persist in the distal nerve stump after the severed nerve fiber degenerates. Basal lamina tubes develop at the stages when regenerative specificity is no longer expressed. These results led to the hypothesis that guidance cues may be present in older animals, and axons may be capable of responding to these cues, but are prevented from doing so because they are confined in basal lamina tubes. Results obtained from crosstage hindlimb transplants are consistent with this hypothesis.
Authors:
P B Farel; M L Meeker
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Brain research bulletin     Volume:  30     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1993  
Date Detail:
Created Date:  1993-04-27     Completed Date:  1993-04-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  483-90     Citation Subset:  IM    
Affiliation:
Department of Physiology, University of North Carolina, Chapel Hill 27599.
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MeSH Terms
Descriptor/Qualifier:
Animals
Axons / physiology
Basement Membrane / growth & development
Hindlimb / innervation
Larva / growth & development,  physiology
Motor Neurons / physiology
Nerve Regeneration / physiology*
Rana catesbeiana
Sensitivity and Specificity
Grant Support
ID/Acronym/Agency:
NS14899/NS/NINDS NIH HHS; NS16030/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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