Document Detail


Developmental regulation of notochord-derived repulsion for dorsal root ganglion axons.
MedLine Citation:
PMID:  15019939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During the initial stages of development, the notochord provides repulsive signals for dorsal root ganglion (DRG) axons via semaphorin 3A/neuropilin-1, axonin-1/SC2, and other unknown repulsive molecules. The notochord is known to produce aggrecan, one of the chondroitin sulfate proteoglycans (CSPGs). We report here that adding aggrecan to the culture medium cannot only induce DRG growth cone collapse, but also inhibit DRG axonal growth. Using cocultures composed of tissues derived from chick embryos or neuropilin-1-deficient mice treated with chondroitinase ABC, we show the direct evidence that CSPGs are involved in notochord-derived repulsion for DRG axons. At later developmental stages, CSPGs are involved in perinotochordal sheath-derived axon repulsion, but not in notochord core-derived repulsion. We further demonstrate that TAG-1/axonin-1/SC2 is not involved in mediating repulsive activities by CSPGs, but is required for notochord core-derived axon repulsion. Thus, notochord-derived multiple axon repulsions act in a spatiotemporal-specific manner to shape the initial trajectories of DRG axons.
Authors:
Tomoyuki Masuda; Fumihiko Fukamauchi; Yasuo Takeda; Hajime Fujisawa; Kazutada Watanabe; Nobuo Okado; Takashi Shiga
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular neurosciences     Volume:  25     ISSN:  1044-7431     ISO Abbreviation:  Mol. Cell. Neurosci.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-03-15     Completed Date:  2004-06-15     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9100095     Medline TA:  Mol Cell Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  217-27     Citation Subset:  IM    
Affiliation:
Department of Anatomy, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aggrecans
Animals
Cell Adhesion Molecules, Neuronal / metabolism
Cell Communication / drug effects,  physiology
Cell Differentiation / drug effects,  physiology
Chick Embryo
Chondroitin ABC Lyase / pharmacology
Coculture Techniques
Extracellular Matrix Proteins*
Ganglia, Spinal / cytology,  embryology,  metabolism*
Gene Expression Regulation, Developmental / physiology*
Growth Cones / metabolism*,  ultrastructure
Lectins, C-Type
Mice
Mice, Knockout
Nerve Growth Factors / metabolism*,  secretion
Neuropilin-1 / deficiency,  genetics
Notochord / metabolism*,  secretion
Organ Culture Techniques
Proteochondroitin Sulfates / metabolism*,  secretion
Proteoglycans / metabolism,  pharmacology
Chemical
Reg. No./Substance:
0/Agc1 protein, mouse; 0/Aggrecans; 0/Cell Adhesion Molecules, Neuronal; 0/Extracellular Matrix Proteins; 0/Lectins, C-Type; 0/Nerve Growth Factors; 0/Proteochondroitin Sulfates; 0/Proteoglycans; 0/contactin 2; 144713-63-3/Neuropilin-1; EC 4.2.2.20/Chondroitin ABC Lyase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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