Document Detail


Developmental regulation of an instability element from the Drosophila fushi tarazu mRNA.
MedLine Citation:
PMID:  11416864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Drosophila fushi tarazu (ftz) mRNA is one of the shortest-lived metazoan mRNAs, and its instability is crucial for proper development of the embryo. Previously, we identified two cis-acting elements that are required for ftz mRNA degradation, one within the 5' one-third and another in the 3'UTR of the message. Here we focus on the 3'UTR element termed FIE3 (ftz instability element in the 3'UTR). To investigate the developmental regulation of the FIE3-dependent degrading activity we measured the abundance of an FIE3-containing mRNA in ovaries, unfertilized eggs, and different larval and adult tissues. We found that FIE3-degrading activity is present at all developmental stages and tissues examined, except in the ovary. Activation of the FIE3-dependent mRNA decay is independent of fertilization because it could be triggered by egg activation. Finally, we provide evidence that mutation of conserved elements within FIE3 had no effect on mRNA instability.
Authors:
A M Fontes; A Riedl; M Jacobs-Lorena
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Publication Detail:
Type:  Letter    
Journal Detail:
Title:  Genesis (New York, N.Y. : 2000)     Volume:  30     ISSN:  1526-954X     ISO Abbreviation:  Genesis     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-20     Completed Date:  2001-10-04     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  100931242     Medline TA:  Genesis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  59-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
3' Untranslated Regions
Animals
Base Sequence
Drosophila / embryology,  genetics*,  metabolism
Drosophila Proteins
Fushi Tarazu Transcription Factors
Gene Expression Regulation, Developmental*
Genes, Insect
Homeodomain Proteins / genetics*
Humans
Models, Biological
Molecular Sequence Data
Mutation
RNA Stability*
RNA, Messenger / genetics*,  metabolism
Regulatory Sequences, Nucleic Acid
Sequence Homology, Nucleic Acid
Chemical
Reg. No./Substance:
0/3' Untranslated Regions; 0/Drosophila Proteins; 0/Fushi Tarazu Transcription Factors; 0/Homeodomain Proteins; 0/RNA, Messenger; 0/ftz protein, Drosophila

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