Document Detail

Developmental regulation of cytokeratins in cells of the rat mammary gland studied with monoclonal antibodies.
MedLine Citation:
PMID:  6199793     Owner:  NLM     Status:  MEDLINE    
We have isolated two monoclonal antibodies to cytokeratins and determined their cell specificities. They display interesting localization within the rat mammary gland. One (1A10) shows specificity for myoepithelial cells; the other (24B42) is specific for lumenal cells at various stages of development. These two monoclonal antibodies and three others to cytokeratin previously isolated were used in conjunction with antibodies to myosin and collagen IV to confirm and extend our previous findings on epithelial cell types and development within the mammary gland.
R Allen; R Dulbecco; P Syka; M Bowman; B Armstrong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  81     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1984-04-24     Completed Date:  1984-04-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1203-7     Citation Subset:  IM    
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MeSH Terms
Antibodies, Monoclonal
Fluorescent Antibody Technique
Immunoenzyme Techniques
Keratins / metabolism*
Mammary Glands, Animal / growth & development*
Tissue Distribution
Grant Support
Reg. No./Substance:
0/Antibodies, Monoclonal; 68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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