Document Detail

Developmental programming of cardiovascular risk in intrauterine growth-restricted twin fetuses according to aortic intima thickness.
MedLine Citation:
PMID:  23341384     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We aimed to test the hypothesis that aortic intima thickness is greater in intrauterine growth-restricted (IUGR) twin fetuses compared to normally developing twins, thus defining an increased cardiovascular risk that reflects genetic factors in fetuses sharing the same womb.
METHODS: We conducted a prospective study performed on twins from January 2009 to July 2011. Twins were classified into 3 groups: IUGR fetuses with an estimated fetal weight below the 10th percentile and an umbilical artery pulsatility index of greater than 2 SDs (group A), fetuses with an estimated fetal weight below the 10th percentile and normal Doppler findings (group B), and fetuses with an estimated fetal weight appropriate for gestational age (group C). Aortic intima thickness was measured at a median gestational age of 32 weeks. Values were compared among groups and between each twin and cotwin, also considering sex and chorionicity.
RESULTS: Twenty-five fetuses were classified as group A, 36 as group B, and 95 as group C. The median aortic intima thickness values were 0.9 mm in group A, 0.7 mm in group B, and 0.6 mm in group C (P < .0001). There was a statistically significant difference between the aortic intima thickness of the twins and cotwins in groups A and B (P < .0001). Sex and chorionicity did not correlate with aortic intima thickness.
CONCLUSIONS: In this study, IUGR fetuses with Doppler abnormalities had greater aortic intima thickness, and IUGR twins with normal Doppler findings had intermediate thickness, supporting a genetic predisposition to cardiovascular risk independent of sex and chorionicity.
Silvia Visentin; Enrico Grisan; Vincenzo Zanardo; Martina Bertin; Elisa Veronese; Francesco Cavallin; Guido Ambrosini; Daniele Trevisanuto; Daniele Trevisanto; Erich Cosmi
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Publication Detail:
Type:  Journal Article; Twin Study    
Journal Detail:
Title:  Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine     Volume:  32     ISSN:  1550-9613     ISO Abbreviation:  J Ultrasound Med     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-23     Completed Date:  2013-06-18     Revised Date:  2013-07-24    
Medline Journal Info:
Nlm Unique ID:  8211547     Medline TA:  J Ultrasound Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  279-84     Citation Subset:  IM    
Department of Woman and Child Health, Maternal-Fetal Medicine Unit, University of Padua School of Medicine, Padua, Italy.
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MeSH Terms
Aorta / embryology*,  ultrasonography*
Blood Flow Velocity
Cardiovascular Diseases / epidemiology
Diseases in Twins / ultrasonography*
Fetal Growth Retardation / epidemiology,  ultrasonography*
Genetic Predisposition to Disease
Laser-Doppler Flowmetry
Pregnancy Trimester, First
Prospective Studies
Pulsatile Flow
Risk Factors
Tunica Intima / ultrasonography*
Ultrasonography, Prenatal
Umbilical Arteries / ultrasonography
Erratum In:
J Ultrasound Med. 2013 Mar;32(3):550
Note: Trevisanto, Daniele [corrected to Trevisanuto, Daniele]

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