Document Detail

Developmental programming of allergic diseases.
MedLine Citation:
PMID:  22767058     Owner:  NLM     Status:  In-Data-Review    
Emerging evidence reveals that the incidence of allergic disorders commencing during childhood is influenced by pre-, peri- and early postnatal environmental challenges. We here highlight biomarkers involved in the purported interaction of a challenged intrauterine environment during pregnancy and the risk for allergies in the children later in life. We propose that the identification of biomarkers during pregnancy may allow early detection of children prone to develop allergies and possibly other chronic immune diseases. Subsequently, therapeutic interventions designed to prevent negative consequences of prenatal environmental challenges on children's immune system would be within reach.
Maike Pincus; Petra Arck
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Publication Detail:
Type:  Journal Article     Date:  2012-06-26
Journal Detail:
Title:  Chemical immunology and allergy     Volume:  98     ISSN:  1662-2898     ISO Abbreviation:  Chem Immunol Allergy     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101183835     Medline TA:  Chem Immunol Allergy     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  70-84     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Department of Pediatrics, Pneumology and Immunology Division, Charité Universitaetsmedizin Berlin, Berlin, Germany.
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