| Developmental program of murine erythroleukemia cells. Effect of the inhibition of protein synthesis. | |
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MedLine Citation:
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PMID: 292644 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relationship between protein synthesis and commitment to terminal erythroid differentiation by dimethylsulfoxide-treated murine erythroleukemia (MEL) cells has been studied. Treatment with cycloheximide blocks the commitment of MEL cells. The effects of cycloheximide are completely reversible, however. Treatment of MEL cells before commitment delays commitment for a period of time equal to the length of inhibitor treatment. Puromycin exerts a similar effect on the commitment of MEL cells. These results indicate that there is a continuous requirement for protein synthesis before the commitment event. |
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Authors:
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R Levenson; D Housman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of cell biology Volume: 82 ISSN: 0021-9525 ISO Abbreviation: J. Cell Biol. Publication Date: 1979 Sep |
Date Detail:
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Created Date: 1980-02-28 Completed Date: 1980-02-28 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0375356 Medline TA: J Cell Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 715-25 Citation Subset: IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation* / drug effects Cell Division / drug effects Cell Line Cycloheximide / pharmacology Dimethyl Sulfoxide / pharmacology Leukemia, Erythroblastic, Acute / metabolism*, pathology Leukemia, Experimental Mice Neoplasm Proteins / biosynthesis* Puromycin / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Neoplasm Proteins; 53-79-2/Puromycin; 66-81-9/Cycloheximide; 67-68-5/Dimethyl Sulfoxide |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Cell Biol ISSN: 0021-9525 ISSN: 1540-8140 Publisher: The Rockefeller University Press |
Article Information Download PDF  Print publication date: Day: 1 Month: 9 Year: 1979 Volume: 82 Issue: 3 First Page: 715 Last Page: 725 ID: 2110478 Publisher Id: 80072225 PubMed Id: 292644 |
| Developmental program of murine erythroleukemia cells. Effect of the inhibition of protein synthesis | |
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