| Developmental pharmacogenomics. | |
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MedLine Citation:
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PMID: 21320234 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Interindividual variability in the disposition and action associated with similar doses of a given medication is an inherent characteristic of both adult and pediatric populations. Genotype-phenotype relationships in infants and children must take into account the role that ontogeny plays in producing variability in both pharmacokinetics and pharmacodynamics. This review explores pharmacogenomics in the context of ontogeny and relates these to the expression of drug-metabolizing enzymes and transporters and the consequent effect on the exposure-response relationship in the early years of life. |
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Authors:
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Kathleen A Neville; Mara L Becker; Jennifer L Goldman; Gregory L Kearns |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Paediatric anaesthesia Volume: 21 ISSN: 1460-9592 ISO Abbreviation: Paediatr Anaesth Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9206575 Medline TA: Paediatr Anaesth Country: France |
Other Details:
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Languages: eng Pagination: 255-65 Citation Subset: IM |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Pediatrics, University of Missouri - Kansas City and the Children's Mercy Hospitals and Clinics, Kansas City, MO, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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