Document Detail


Developmental patterns in the cytoarchitecture of the human cerebral cortex from birth to 6 years examined by correspondence analysis.
MedLine Citation:
PMID:  9520486     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper uses correspondence analysis to examine the developmental patterns in the cytoarchitecture of the human cerebral cortex from birth to 72 months. The study is based on data collected by the late J. L. Conel, which consist of over 4 million individual measurements of six microscopic neuroanatomic features for each of six cortical layers in 46 cytoarchitecturally distinct regions. We analyze 1,727 profiles of development over eight age-points (term birth, 1, 3, 6, 15, 24, 48, and 72 postnatal months) resulting from the combinations of neuroanatomic feature, cortical layer, and brain cytoarchitectural region in the Conel data. The profiles for any given combination of feature and layer are found to be remarkably similar in all regions of the brain, and therefore the developmental patterns of different cytoarchitectural regions are not distinguishable from one another. Developmental change is most rapid at the earlier stages; of the total change in profile patterns observed, more than one-third occurs between birth and 6 months, about one-third occurs between 6 and 15 months, and less than one-third occurs between 15 and 72 months. The majority of the variance in developmental profiles is accounted for by the six microscopic, neuroanatomic features. Correspondence analysis shows that Conel's data are highly consistent and reliable.
Authors:
W R Shankle; A K Romney; B H Landing; J Hara
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  95     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-05-01     Completed Date:  1998-05-01     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4023-8     Citation Subset:  IM    
Affiliation:
Department of Cognitive Science, University of California, Irvine, CA 92697-5100, USA. rshankle@uci.edu
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MeSH Terms
Descriptor/Qualifier:
Aging
Cerebral Cortex / cytology*,  growth & development
Child
Child, Preschool
Humans
Infant
Infant, Newborn
Multivariate Analysis
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