Document Detail


Developmental pattern of expression of NPDC-1 and its interaction with E2F-1 suggest a role in the control of proliferation and differentiation of neural cells.
MedLine Citation:
PMID:  9469579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have previously identified NPDC-1, a gene specifically expressed in neural cells and involved in the control of cell proliferation and differentiation. In the present study, we have investigated the expression of this gene during mouse development and the interactions of the NPDC-1 protein with cell cycle regulatory proteins. The data show that NPDC-1 mRNA begins to be expressed in a variety of neural structures when the precursors enter into their terminal differentiation. They also indicate that in adult brain, the expression patterns of NPDC-1 and E2F-1 mRNA largely overlap. In addition, the NPDC-1 protein is able to interact directly with the transcription factor E2F-1 that participates in the regulation of the cell cycle, cell survival, and apoptosis. The present results suggest that NPDC-1 might be involved in the terminal differentiation and survival of neural cells and might act through interactions with E2F-1.
Authors:
E Dupont; I Sansal; C Evrard; P Rouget
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroscience research     Volume:  51     ISSN:  0360-4012     ISO Abbreviation:  J. Neurosci. Res.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-03-30     Completed Date:  1998-03-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7600111     Medline TA:  J Neurosci Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  257-67     Citation Subset:  IM    
Affiliation:
Unité de Génétique Oncologique, CNRS-URA 1967, Institut Gustave Roussy, Villejuif, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blotting, Northern
Carrier Proteins*
Cell Cycle Proteins / biosynthesis*
Cell Differentiation / physiology
Cell Division / physiology
Cell Line
Cells, Cultured
DNA-Binding Proteins*
E2F Transcription Factors
E2F1 Transcription Factor
Female
Immunohistochemistry
In Situ Hybridization
Mice
Nerve Tissue Proteins / biosynthesis*
Neurons / metabolism*,  physiology
PC12 Cells
Pregnancy
RNA, Messenger / biosynthesis
Rats
Retinoblastoma-Binding Protein 1
Transcription Factor DP1
Transcription Factors / biosynthesis*
Chemical
Reg. No./Substance:
0/Arid4a protein, mouse; 0/Carrier Proteins; 0/Cell Cycle Proteins; 0/DNA-Binding Proteins; 0/E2F Transcription Factors; 0/E2F1 Transcription Factor; 0/E2f1 protein, mouse; 0/E2f1 protein, rat; 0/Nerve Tissue Proteins; 0/Npdc1 protein, mouse; 0/RNA, Messenger; 0/Retinoblastoma-Binding Protein 1; 0/Transcription Factor DP1; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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