Document Detail


Developmental pattern of 17 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase activities in the foreskin of boys from birth to eight years of age.
MedLine Citation:
PMID:  2560455     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The normal developmental pattern of 17 beta-hydroxysteroid dehydrogenase (17HSD) activity in genital skin was examined using radiolabeled androstenedione as a substrate in a microassay based on high-pressure liquid chromatography separation of the metabolites. This assay allowed the simultaneous determination of 17HSD and 5 alpha-reductase (5R) activities in both individual foreskin samples and pools of tissue obtained at circumcision from birth to 8 years of age. The results show that 17HSD activity is very low at birth and increases steadily during the so-called quiescent period. Reciprocal changes were observed for 5R. The increase in 17HSD activity appears to be independent of gonadal stimulation, but the mechanisms involved remain to be elucidated. From a clinical standpoint, our results provide an alternative explanation for the relative lack of virilization observed in newborns with testicular 17HSD deficiency.
Authors:
G E Theintz; T J Steimer; P C Sizonenko
Related Documents :
9099315 - Skin microcirculation before and after local warming in infants delivered vaginally or ...
16871945 - Decreased nasal mucosal sensitivity in older subjects.
1934155 - Myiasis due to cardylobia anthropophaga, the 'tumbu fly' in a sri lankan infant.
894425 - Clinical pharmacology of hexachlorophene in newborn infants.
8463915 - Lactic acid as a predictor for erythrocyte transfusion in healthy preterm infants with ...
19139085 - Twin gestation and neurodevelopmental outcome in extremely low birth weight infants.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hormone research     Volume:  32     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  1989  
Date Detail:
Created Date:  1990-04-09     Completed Date:  1990-04-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  124-9     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Canton University Hospital, Geneva, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
17-Hydroxysteroid Dehydrogenases / metabolism*
Aging / metabolism*
Androstenedione / metabolism*
Child
Child, Preschool
Chromatography, High Pressure Liquid
Humans
Infant
Infant, Newborn
Male
Penis / enzymology,  growth & development*,  metabolism
Skin / enzymology,  growth & development*,  metabolism
Testosterone 5-alpha-Reductase / metabolism*
Chemical
Reg. No./Substance:
63-05-8/Androstenedione; EC 1.1.-/17-Hydroxysteroid Dehydrogenases; EC 1.1.1.63/testosterone 17 beta-dehydrogenase; EC 1.3.99.5/Testosterone 5-alpha-Reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Different effects of aging on the opioid mechanisms controlling gonadotropin and cortisol secretion ...
Next Document:  Relationship of parathyroid adenoma volume and biochemical function.