Document Detail

Developmental pattern of 17 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase activities in the foreskin of boys from birth to eight years of age.
MedLine Citation:
PMID:  2560455     Owner:  NLM     Status:  MEDLINE    
The normal developmental pattern of 17 beta-hydroxysteroid dehydrogenase (17HSD) activity in genital skin was examined using radiolabeled androstenedione as a substrate in a microassay based on high-pressure liquid chromatography separation of the metabolites. This assay allowed the simultaneous determination of 17HSD and 5 alpha-reductase (5R) activities in both individual foreskin samples and pools of tissue obtained at circumcision from birth to 8 years of age. The results show that 17HSD activity is very low at birth and increases steadily during the so-called quiescent period. Reciprocal changes were observed for 5R. The increase in 17HSD activity appears to be independent of gonadal stimulation, but the mechanisms involved remain to be elucidated. From a clinical standpoint, our results provide an alternative explanation for the relative lack of virilization observed in newborns with testicular 17HSD deficiency.
G E Theintz; T J Steimer; P C Sizonenko
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hormone research     Volume:  32     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  1989  
Date Detail:
Created Date:  1990-04-09     Completed Date:  1990-04-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  124-9     Citation Subset:  IM    
Department of Pediatrics, Canton University Hospital, Geneva, Switzerland.
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MeSH Terms
17-Hydroxysteroid Dehydrogenases / metabolism*
Aging / metabolism*
Androstenedione / metabolism*
Child, Preschool
Chromatography, High Pressure Liquid
Infant, Newborn
Penis / enzymology,  growth & development*,  metabolism
Skin / enzymology,  growth & development*,  metabolism
Testosterone 5-alpha-Reductase / metabolism*
Reg. No./Substance:
63-05-8/Androstenedione; EC 1.1.-/17-Hydroxysteroid Dehydrogenases; EC 17 beta-dehydrogenase; EC 5-alpha-Reductase

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